PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. - Wikidata - wikimedia - TriplyDB

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.

http://www.wikidata.org/entity/Q37407269

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Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1 Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Modes of resistance to anti-angiogenic therapy Role of pericytes in skeletal muscle regeneration and fat accumulation The Foxc2 transcription factor regulates tumor angiogenesis Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization The role of pericytes in blood-vessel formation and maintenance Tumor refractoriness to anti-VEGF therapy Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature within the Process of Vascular Remodeling: Cellular Basis, Clinical Relevance, and Implications for Stem Cell Therapy Brain and Retinal Pericytes: Origin, Function and Role Structural and functional properties of platelet-derived growth factor and stem cell factor receptors Circulating glioma biomarkers Intertwined regulation of angiogenesis and immunity by myeloid cells Pericyte dynamics during angiogenesis: new insights from new identities Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications Diversified expression of NG2/CSPG4 isoforms in glioblastoma and human foetal brain identifies pericyte subsets Mural cell associated VEGF is required for organotypic vessel formation Adaptation to antiangiogenic therapy in neurological tumors Theranostic impact of NG2/CSPG4 proteoglycan in cancer Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Endothelial progenitor cells: identity defined?Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting Molecular mechanisms and clinical applications of angiogenesis Microenvironmental regulation of metastasis Targeting pericytes for angiogenic therapies.Opportunities and challenges for successful use of bevacizumab in pediatrics.Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis.Tumors as organs: complex tissues that interface with the entire organism VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.Targeting pericytes diminishes neovascularization in orthotopic uveal melanoma in nerve/glial antigen 2 proteoglycan knockout mouse Smooth muscle actin expression in primary bone tumours.Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model

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PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.

http://www.wikidata.org/entity/Q37407269

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 21 August 2005

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

PDGFRbeta+ perivascular progen ...... tiation and vascular survival.

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PDGFRbeta+ perivascular progen ...... tiation and vascular survival.

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type

label

PDGFRbeta+ perivascular progen ...... tiation and vascular survival.

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PDGFRbeta+ perivascular progen ...... tiation and vascular survival.

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prefLabel

PDGFRbeta+ perivascular progen ...... tiation and vascular survival.

@en

PDGFRbeta+ perivascular progen ...... tiation and vascular survival.

@nl

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Nature Cell Biology

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PDGFRbeta+ perivascular progen ...... tiation and vascular survival.

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Andrew J Ewald

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Gabriele Bergers

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Steven Song

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William Stallcup

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Zena Werb

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P2860

Mechanism of action and in vivo role of platelet-derived growth factor

NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis

PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis

Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

Vascular-specific growth factors and blood vessel formation

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

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10.1038/NCB1288

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