Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.
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Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell linesADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage.10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furinAdult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes.Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis.A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophyCharacterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinaseMechanical Loading of Articular Cartilage Reduces IL-1-Induced Enzyme ExpressionThe effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilageNitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants.Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degenerationResponse of cartilage and meniscus tissue explants to in vitro compressive overload.Metabolic Response of Human Osteoarthritic Cartilage to Biochemically Characterized Collagen Hydrolysates.What are the roles of metalloproteinases in cartilage and bone damage?Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancerMechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repairCell death-associated ADAMTS4 and versican degradation in vascular tissue.Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold.Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 bNew Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane-Anchored MMPs with Therapeutic Antibodies.The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model.Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long termMetalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment.Adipokines induce catabolism of newly synthesized matrix in cartilage and meniscus tissues.The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects.Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration.
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Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2005
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Analysis of ADAMTS4 and MT4-MM ...... in-1-treated bovine cartilage.
@en
Analysis of ADAMTS4 and MT4-MM ...... in-1-treated bovine cartilage.
@nl
type
label
Analysis of ADAMTS4 and MT4-MM ...... in-1-treated bovine cartilage.
@en
Analysis of ADAMTS4 and MT4-MM ...... in-1-treated bovine cartilage.
@nl
prefLabel
Analysis of ADAMTS4 and MT4-MM ...... in-1-treated bovine cartilage.
@en
Analysis of ADAMTS4 and MT4-MM ...... in-1-treated bovine cartilage.
@nl
P2093
P2860
P1476
Analysis of ADAMTS4 and MT4-MM ...... in-1-treated bovine cartilage.
@en
P2093
P2860
P304
P356
10.1016/J.JOCA.2004.10.023
P577
2005-04-01T00:00:00Z