Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine. - Wikidata - wikimedia - TriplyDB

Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine.

Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine.

http://www.wikidata.org/entity/Q37409489

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Virion Glycoprotein-Mediated Immune Evasion by Human Cytomegalovirus: a Sticky Virus Makes a Slick Getaway A neutralizing anti-gH/gL monoclonal antibody is protective in the guinea pig model of congenital CMV infection The immunological underpinnings of vaccinations to prevent cytomegalovirus disease.Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies Efficient generation of monoclonal antibodies from single rhesus macaque antibody secreting cells.Using the nonhuman primate model of HCMV to guide vaccine development Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell types Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes.Soluble Human Cytomegalovirus gH/gL/pUL128-131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes Vaccination with a Live Attenuated Cytomegalovirus Devoid of a Protein Kinase R Inhibitory Gene Results in Reduced Maternal Viremia and Improved Pregnancy Outcome in a Guinea Pig Congenital Infection Model.The Cellular Localization of Human Cytomegalovirus Glycoprotein Expression Greatly Influences the Frequency and Functional Phenotype of Specific CD4+ T Cell Responses.The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH/gL Pentamer Potently Block Primary Cytotrophoblast Infection.Cytomegalovirus Genotype Distribution Among Congenitally and Postnatally Infected Patients: Association of Particular Glycoprotein (g)B and gN Types With Symptomatic Disease.A cytomegalovirus DNA vaccine induces antibodies that block viral entry into fibroblasts and epithelial cells.The Human Cytomegalovirus UL116 Gene Encodes an Envelope Glycoprotein Forming a Complex with gH Independently from gL Monoclonal Antibodies to Different Components of the Human Cytomegalovirus (HCMV) Pentamer gH/gL/pUL128L and Trimer gH/gL/gO as well as Antibodies Elicited during Primary HCMV Infection Prevent Epithelial Cell Syncytium Formation.gH/gL supercomplexes at early stages of herpesvirus entry Repair of a Mutation Disrupting the Guinea Pig Cytomegalovirus Pentameric Complex Acquired during Fibroblast Passage Restores Pathogenesis in Immune-Suppressed Guinea Pigs and in the Context of Congenital Infection.Preclinical evaluations of peptide-conjugate vaccines targeting the antigenic domain-2 of glycoprotein B of human cytomegalovirus.Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex.Design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach.Human cytomegalovirus: taking the strain.Impact of Antibodies and Strain Polymorphisms on Cytomegalovirus Entry and Spread in Fibroblasts and Epithelial Cells.Genomic analysis of chimeric human cytomegalovirus vaccine candidates derived from strains Towne and Toledo Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission.Functional analysis of human cytomegalovirus UL/b' region using SCID-hu mouse model.Cytomegalovirus Vaccines: Current Status and Future Prospects.Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro.The proteome of human cytomegalovirus virions and dense bodies is conserved across different strains.Diagnosis, gB genotype distribution and viral load of symptomatic congenitally infected CMV patients in Cuba.Expression of the human cytomegalovirus pentamer complex for vaccine use in a CHO system.Human Cytomegalovirus Particles Treated with Specific Antibodies Induce Intrinsic and Adaptive but Not Innate Immune Responses.The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus.Cytomegalovirus Virions Shed in Urine Have a Reversible Block to Epithelial Cell Entry and Are Highly Resistant to Antibody Neutralization.Identification of a Continuous Neutralizing Epitope within UL128 of Human Cytomegalovirus.Complement enhances in vitro neutralizing potency of antibodies to human cytomegalovirus glycoprotein B (gB) and immune sera induced by gB/MF59 vaccination.Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection.

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Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine.

http://www.wikidata.org/entity/Q37409489

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 02 December 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Pentameric complex of viral gl ...... human cytomegalovirus vaccine.

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Pentameric complex of viral gl ...... human cytomegalovirus vaccine.

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type

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Pentameric complex of viral gl ...... human cytomegalovirus vaccine.

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Pentameric complex of viral gl ...... human cytomegalovirus vaccine.

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prefLabel

Pentameric complex of viral gl ...... human cytomegalovirus vaccine.

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Pentameric complex of viral gl ...... human cytomegalovirus vaccine.

@nl

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PNAS.1316517110

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Proceedings of the National Academy of Sciences of the United States of America

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Pentameric complex of viral gl ...... human cytomegalovirus vaccine.

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Adam C Finnefrock

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Aimin Tang

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Amy S Espeseth

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Daniel C Freed

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Danilo R Casimiro

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Eberhard Durr

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Fengsheng Li

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John W Shiver

http://www.w3.org/2001/XMLSchema#string

Lin Xia

http://www.w3.org/2001/XMLSchema#string

Ningyan Zhang

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Definitions of cytomegalovirus infection and disease in transplant recipients

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A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models

The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies.

Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex.

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E4997-5005

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scholarly article

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10.1073/PNAS.1316517110

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2013-12-02T00:00:00Z

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259115153

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24297878

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Cytomegalovirus

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3870741

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