The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells.
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New perspectives in glioblastoma antiangiogenic therapyGlioblastoma Stem Cells as a New Therapeutic Target for GlioblastomaJudicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesCombined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivoSynergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma.KML001, a telomere-targeting drug, sensitizes glioblastoma cells to temozolomide chemotherapy and radiotherapy through DNA damage and apoptosis.Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.AZD2014 Radiosensitizes Oral Squamous Cell Carcinoma by Inhibiting AKT/mTOR Axis and Inducing G1/G2/M Cell Cycle Arrest.MicroRNA-199a-3p suppresses glioma cell proliferation by regulating the AKT/mTOR signaling pathwayCoculture with astrocytes reduces the radiosensitivity of glioblastoma stem-like cells and identifies additional targets for radiosensitization.Polysome Profiling Links Translational Control to the Radioresponse of Glioblastoma Stem-like Cells.RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes.Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell Line.Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway.Rapamycin inhibited the function of lung CSCs via SOX2.Recent advances in targeting mTOR signaling pathway using small molecule inhibitors.TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2.Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model.Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cellsDownregulation of lncRNA X Inactive Specific Transcript (XIST) Suppresses Cell Proliferation and Enhances Radiosensitivity by Upregulating mir-29c in Nasopharyngeal Carcinoma Cells.Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma.Radiomics: the bridge between medical imaging and personalized medicine.Exploiting radiation-induced signaling to increase the susceptibility of resistant cancer cells to targeted drugs: AKT and mTOR inhibitors as an example.Identification of expression quantitative trait loci of MTOR associated with the progression of glioma.A randomized phase II study of everolimus in combination with chemoradiation in newly diagnosed glioblastoma: Results of NRG Oncology RTOG 0913.
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The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The mTORC1/mTORC2 inhibitor AZ ...... glioblastoma stem-like cells.
@en
The mTORC1/mTORC2 inhibitor AZ ...... glioblastoma stem-like cells.
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type
label
The mTORC1/mTORC2 inhibitor AZ ...... glioblastoma stem-like cells.
@en
The mTORC1/mTORC2 inhibitor AZ ...... glioblastoma stem-like cells.
@nl
prefLabel
The mTORC1/mTORC2 inhibitor AZ ...... glioblastoma stem-like cells.
@en
The mTORC1/mTORC2 inhibitor AZ ...... glioblastoma stem-like cells.
@nl
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The mTORC1/mTORC2 inhibitor AZ ...... f glioblastoma stem-like cells
@en
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Barbara H Rath
Jenna Kahn
Kevin Camphausen
Muhammad Jamal
Philip J Tofilon
Tamalee Kramp
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P356
10.1093/NEUONC/NOT139
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2013-12-04T00:00:00Z