The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.

The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.

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http://www.wikidata.org/entity/Q37412314
Initial solid tumor testing (stage 1) of AZD1480, an inhibitor of Janus kinases 1 and 2 by the pediatric preclinical testing program.Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer.JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth.Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth.Role of STAT3 in lung cancer.MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitorsProtein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives.Emerging cytokine networks in colorectal cancer.Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.Tumour-associated macrophage-mediated survival of myeloma cells through STAT3 activation.Targeting the IL-6/JAK/STAT3 signalling axis in cancer.
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The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.

Item
http://www.wikidata.org/entity/Q37412314
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Janus kinases inhibitor AZ ...... cancers in vitro and in vivo.
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The Janus kinases inhibitor AZ ...... cancers in vitro and in vivo.
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type
label
The Janus kinases inhibitor AZ ...... cancers in vitro and in vivo.
@en
The Janus kinases inhibitor AZ ...... cancers in vitro and in vivo.
@nl
prefLabel
The Janus kinases inhibitor AZ ...... cancers in vitro and in vivo.
@en
The Janus kinases inhibitor AZ ...... cancers in vitro and in vivo.
@nl
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The Janus kinases inhibitor AZ ...... cancers in vitro and in vivo.
@en
P2093
P2860
P304
P31
P356
10.1158/1078-0432.CCR-13-1110
P407
P433
P478
P50
P577
P5875
P698
P932