Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia.
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Novel immunotherapeutic approaches for the treatment of acute leukemia (myeloid and lymphoblastic)Regulatory T cell: a protection for tumour cellsTargeting the innate immune system as immunotherapy for acute myeloid leukemiaNatural Killer Defective Maturation Is Associated with Adverse Clinical Outcome in Patients with Acute Myeloid Leukemia.Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein.Allogeneic natural killer cells for refractory lymphomaProgram death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growthTargeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects.PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells.Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytesMinimal residual disease following allogeneic hematopoietic stem cell transplantation.New strategies in acute myelogenous leukemia: leukemogenesis and personalized medicine.Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemiaRegulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function.Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells.Elevated lymphocyte count at time of acute myeloid leukemia diagnosis is associated with shorter remission.Programmed death-1 checkpoint blockade in acute myeloid leukemia.A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer.How to detour Treg cells in T cell-based antitumor immune therapy.The biology of NK cells and their receptors affects clinical outcomes after hematopoietic cell transplantation (HCT).Enhancing adoptive immunotherapy of cancer.Immunotherapy prospects for acute myeloid leukaemia.T regulatory cells in cancer: recent advances and therapeutic potential.Use of allogeneic NK cells for cancer immunotherapy.Immune evasion in acute myeloid leukemia: current concepts and future directions.The targeting of immunosuppressive mechanisms in hematological malignancies.Umbilical cord blood graft engineering: challenges and opportunities.Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression.Increased regulatory T cells in acute lymphoblastic leukemia patients.Mechanisms of Immune Tolerance in Leukemia and Lymphoma.Increased regulatory T cells in acute lymphoblastic leukaemia patients.Extracts of Devil's club (Oplopanax horridus) exert therapeutic efficacy in experimental models of acute myeloid leukemia.Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art.Monocyte chemoattractant protein 1 (MCP-1/CCL2) contributes to thymus atrophy in acute myeloid leukemia.A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantationImmunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment.SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines.Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.
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Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on September 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Depletion of endogenous tumor- ...... murine acute myeloid leukemia.
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Depletion of endogenous tumor- ...... murine acute myeloid leukemia.
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type
label
Depletion of endogenous tumor- ...... murine acute myeloid leukemia.
@en
Depletion of endogenous tumor- ...... murine acute myeloid leukemia.
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prefLabel
Depletion of endogenous tumor- ...... murine acute myeloid leukemia.
@en
Depletion of endogenous tumor- ...... murine acute myeloid leukemia.
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Depletion of endogenous tumor- ...... murine acute myeloid leukemia.
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Brenda J Weigel
Bruce L Levine
Carl H June
Christoph Bucher
Daniel A Vallera
David H Munn
Megan Riddle
Meghan E Munger
Steven L Highfill
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P304
P356
10.1182/BLOOD-2009-03-208181
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P577
2009-09-01T00:00:00Z