Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. - Wikidata - wikimedia - TriplyDB

Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.

Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.

http://www.wikidata.org/entity/Q37413060

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Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function Pharmacological chaperoning: a primer on mechanism and pharmacology Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions Inside-out neuropharmacology of nicotinic drugs Mechanistic insights into nicotine withdrawal.X-ray structure of the human α4β2 nicotinic receptor Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages.Functional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors.A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences.A Drosophila model for developmental nicotine exposure.Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences.Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors Using pharmacological chaperones to restore proteostasis GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors Reward, addiction, withdrawal to nicotine.Nicotine: specific role in angiogenesis, proliferation and apoptosis.A component of Premarin(®) enhances multiple cognitive functions and influences nicotinic receptor expression.Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum.Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward.Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse.Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure.Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus.Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons.Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor.Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses.Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors.Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors.Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response.The nicotine metabolite, cotinine, alters the assembly and trafficking of a subset of nicotinic acetylcholine receptors.Nicotine exposure during adolescence alters the rules for prefrontal cortical synaptic plasticity during adulthood Förster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic α4β2.Chrna5 genotype determines the long-lasting effects of developmental in vivo nicotine exposure on prefrontal attention circuitry

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Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.

http://www.wikidata.org/entity/Q37413060

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 12 March 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Nicotine is a selective pharma ...... plications for drug discovery.

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Nicotine is a selective pharma ...... plications for drug discovery.

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type

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Nicotine is a selective pharma ...... plications for drug discovery.

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Nicotine is a selective pharma ...... plications for drug discovery.

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prefLabel

Nicotine is a selective pharma ...... plications for drug discovery.

@en

Nicotine is a selective pharma ...... plications for drug discovery.

@nl

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The AAPS Journal

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Nicotine is a selective pharma ...... mplications for drug discovery

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Cheng Xiao

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Dennis A Dougherty

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Jen C Wang

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Matthew R Banghart

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Rahul Srinivasan

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Rigo Pantoja

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P2860

Nicotine's defensive function in nature

Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking

A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

Nicotine binding to brain receptors requires a strong cation-pi interaction

Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response

Adapting proteostasis for disease intervention

Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts

How mutations in the nAChRs can cause ADNFLE epilepsy

Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine

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s12248-009-9090-7

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167-177

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scholarly article

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10.1208/S12248-009-9090-7

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b9391525fc3ca03a6742aa0d414f0c2f757d6b9e

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2009-03-12T00:00:00Z

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24195290

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1039078308

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19280351

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molecular chaperones

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