--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation. - Wikidata - wikimedia - TriplyDB

--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.

--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.

http://www.wikidata.org/entity/Q37415204

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NF-κB Pathway in Autoinflammatory Diseases: Dysregulation of Protein Modifications by Ubiquitin Defines a New Category of Autoinflammatory Diseases.Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.Linear ubiquitin chains: enzymes, mechanisms and biology The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes.Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection.Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Autophagy regulates apoptosis on the level of the death-inducing signalling complex.Autophagy and Ubiquitination in Salmonella Infection and the Related Inflammatory Responses.LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

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--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.

http://www.wikidata.org/entity/Q37415204

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 24 October 2016

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

--LUBAC deficiency perturbs TL ...... ficiency and autoinflammation.

@en

--LUBAC deficiency perturbs TL ...... ficiency and autoinflammation.

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type

label

--LUBAC deficiency perturbs TL ...... ficiency and autoinflammation.

@en

--LUBAC deficiency perturbs TL ...... ficiency and autoinflammation.

@nl

prefLabel

--LUBAC deficiency perturbs TL ...... ficiency and autoinflammation.

@en

--LUBAC deficiency perturbs TL ...... ficiency and autoinflammation.

@nl

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Journal of Experimental Medicine

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--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation

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Eva Rieser

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Henning Walczak

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Johannes Lemke

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Julia Zinngrebe

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Lucia Taraborrelli

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Maurice Darding

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Peter Draber

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Silvia von Karstedt

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Torsten Hartwig

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P2860

Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

Linear ubiquitination prevents inflammation and regulates immune signalling

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

A ubiquitin ligase complex assembles linear polyubiquitin chains

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

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2671-2689

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scholarly article

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10.1084/JEM.20160041

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12

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213

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Brian J Ferguson

Michael Bergmann

Ildikó Kovács

Cornelia Endres

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2016-10-24T00:00:00Z

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27810922

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Toll-like receptor

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5110014

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