The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. - Wikidata - wikimedia - TriplyDB

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

http://www.wikidata.org/entity/Q37420518

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Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models Regulation of Bim in Health and Disease Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia.PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo.MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis.Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress.Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.High Prevalence of the BIM Deletion Polymorphism in Young Female Breast Cancer in an East Asian Country.BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.Preclinical testing of PI3K/AKT/mTOR signaling inhibitors in a mouse model of ovarian endometrioid adenocarcinoma.The Akt inhibitor MK2206 synergizes, but perifosine antagonizes, the BRAF(V600E) inhibitor PLX4032 and the MEK1/2 inhibitor AZD6244 in the inhibition of thyroid cancer cells LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism.Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome.Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells.Tyrosine kinase gene rearrangements in epithelial malignancies.Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers mTOR kinase inhibitors as a treatment strategy in hematological malignancies.Perifosine--a new option in treatment of acute myeloid leukemia?Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting Synergistic anticancer efficacy of MEK inhibition and dual PI3K/mTOR inhibition in castration-resistant prostate cancer.MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine.The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma.The Development of Novel Therapies for the Treatment of Acute Myeloid Leukemia (AML).dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence.[Effect and Significance of BIM on Non-small Cell Lung Cancer].

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The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

http://www.wikidata.org/entity/Q37420518

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 22 September 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

The BH3-only protein Bim plays ...... K/Akt and MEK/ERK1/2 pathways.

@en

The BH3-only protein Bim plays ...... K/Akt and MEK/ERK1/2 pathways.

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type

label

The BH3-only protein Bim plays ...... K/Akt and MEK/ERK1/2 pathways.

@en

The BH3-only protein Bim plays ...... K/Akt and MEK/ERK1/2 pathways.

@nl

prefLabel

The BH3-only protein Bim plays ...... K/Akt and MEK/ERK1/2 pathways.

@en

The BH3-only protein Bim plays ...... K/Akt and MEK/ERK1/2 pathways.

@nl

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BLOOD-2008-09-177881

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The BH3-only protein Bim plays ...... K/Akt and MEK/ERK1/2 pathways.

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Andrea Ferreira-Gonzalez

http://www.w3.org/2001/XMLSchema#string

Anh Anderson

http://www.w3.org/2001/XMLSchema#string

Hisashi Harada

http://www.w3.org/2001/XMLSchema#string

Joseph Reza Habibi

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Mandy Mayo

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Mohamed Rahmani

http://www.w3.org/2001/XMLSchema#string

Steven Grant

http://www.w3.org/2001/XMLSchema#string

Timothy Ryan Crabtree

http://www.w3.org/2001/XMLSchema#string

P2860

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

The Bcl-2 apoptotic switch in cancer development and therapy

Movement of Bax from the cytosol to mitochondria during apoptosis

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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4507-4516

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scholarly article

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10.1182/BLOOD-2008-09-177881

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20

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114

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2009-09-22T00:00:00Z

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19773546

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