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Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNALung carcinogenesis by tobacco smokeA comprehensive catalogue of somatic mutations from a human cancer genomeGenomic sequencing in cancerBiochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNACrystal Structure of Human Methyl-Binding Domain IV Glycosylase Bound to Abasic DNAStructural Basis for Promutagenicity of 8-Halogenated GuanineRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesExpression of TIP-1 confers radioresistance of malignant glioma cellsGuanine holes are prominent targets for mutation in cancer and inherited diseaseDetection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanoporeDependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairsThe inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.Identification of a novel germ-line mutation in the TP53 gene in a Mexican family with Li-Fraumeni syndrome.TP53 mutations in human cancers: origins, consequences, and clinical useArsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.Genetic mutation analysis of human gastric adenocarcinomas using ion torrent sequencing platform.Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.Temperature and electrolyte optimization of the α-hemolysin latch sensing zone for detection of base modification in double-stranded DNA.Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.Unveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock-in (Hupki) mouse genome.Effect of an Electrolyte Cation on Detecting DNA Damage with the Latch Constriction of α-Hemolysin.An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation.TP53 mutations in nonsmall cell lung cancerStoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNACarcinogenicity of ambient air pollution: use of biomarkers, lessons learnt and future directionsFrequent mutations in EGFR, KRAS and TP53 genes in human lung cancer tumors detected by ion torrent DNA sequencing.On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.The Mechanism of Environmental Endocrine Disruptors (DEHP) Induces Epigenetic Transgenerational Inheritance of Cryptorchidism.Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis.Identification of Genetic Mutations in Human Lung Cancer by Targeted Sequencing.The somatic autosomal mutation matrix in cancer genomes.p53 staining correlates with tumor type and location in sebaceous neoplasms.Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneityCHEMICAL SELECTIVITY OF NUCLEOBASE ADDUCTION RELATIVE TO IN VIVO MUTATION SITES ON EXON 7 FRAGMENT OF P53 TUMOR SUPPRESSOR GENEUnzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutational spectra of human cancer.
@en
Mutational spectra of human cancer.
@nl
type
label
Mutational spectra of human cancer.
@en
Mutational spectra of human cancer.
@nl
prefLabel
Mutational spectra of human cancer.
@en
Mutational spectra of human cancer.
@nl
P2860
P1433
P1476
Mutational spectra of human cancer
@en
P2093
Gerd P Pfeifer
P2860
P2888
P304
P356
10.1007/S00439-009-0657-2
P577
2009-03-24T00:00:00Z