Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
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NMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's diseaseOverview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal CompoundsClose Correlation of Monoamine Oxidase Activity with Progress of Alzheimer's Disease in Mice, Observed by in Vivo Two-Photon ImagingA turn-on fluorescence chemosensor based on a tripodal amine [tris(pyrrolyl-α-methyl)amine]-rhodamine conjugate for the selective detection of zinc ions.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Effect of metals on kinetic pathways of amyloid-β aggregationA gadolinium(III) complex with 8-amidequinoline based ligand as copper(II) ion responsive contrast agent.Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.A series of tripodal cysteine derivatives as water-soluble chelators that are highly selective for copper(I).MRI probes for sensing biologically relevant metal ions.Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.ESEEM analysis of multi-histidine Cu(II)-coordination in model complexes, peptides, and amyloid-βZinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.NMR, DFT and luminescence studies of the complexation of Zn(II) with 8-hydroxyquinoline-5-sulfonate.Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.Reevaluation of copper(I) affinity for amyloid-β peptides by competition with ferrozine--an unusual copper(I) indicator.Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-beta copper complex follow a preorganization mechanism.Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseDesign of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β SpeciesInterplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization.Cu(2+) affects amyloid-β (1-42) aggregation by increasing peptide-peptide binding forces.Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers.Calorimetric investigation of copper binding in the N-terminal region of the prion protein at low copper loading: evidence for an entropically favorable first binding event.Molecular dynamics study of Zn(aβ) and Zn(aβ)2Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in amyloid-β(1-16) at physiological pH and its significance.Misfolded proteins in Alzheimer's disease and type II diabetes.Environmental factors preceding aβ40 monomer to oligomers and the detection of oligomers in Alzheimer's disease patient serumStudies on the interactions of copper and zinc ions with β-amyloid peptides by a surface plasmon resonance biosensor.The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaquesReactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease.Zn(II) ions substantially perturb Cu(II) ion coordination in amyloid-β at physiological pH.Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.Dicarboxylated ethynylarenes as buffer-dependent chemosensors for Cd(II), Pb(II) and Zn(II)Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease.Novel drug targets based on metallobiology of Alzheimer's disease.Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity.
P2860
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P2860
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
@en
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
@nl
type
label
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
@en
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
@nl
prefLabel
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
@en
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
@nl
P2860
P356
P1433
P1476
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.
@en
P2093
Christelle Hureau
Peter Faller
P2860
P304
P356
10.1039/B813398K
P407
P577
2008-11-26T00:00:00Z