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Environmental standardization: cure or cause of poor reproducibility in animal experiments?

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

http://www.wikidata.org/entity/Q37427393

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Robust and sensitive analysis of mouse knockout phenotypes Estimating Information Processing in a Memory System: The Utility of Meta-analytic Methods for Genetics Show and tell: disclosure and data sharing in experimental pathology The Snark was a Boojum - reloaded Refinement of Experimental Design and Conduct in Laboratory Animal Research The role of behavior in translational models for psychopathology: functionality and dysfunctional behaviors The significance of meaning: why do over 90% of behavioral neuroscience results fail to translate to humans, and what can we do to fix it?Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study The role of genetics in the etiology of schizophrenia Sex-dependent behavioral functions of the Purkinje cell-specific Gαi/o binding protein, Pcp2(L7).Effects of Enrichment and Litter Parity on Reproductive Performance and Behavior in BALB/c and 129/Sv Mice.Co-housing rodents with different coat colours as a simple, non-invasive means of individual identification: validating mixed-strain housing for C57BL/6 and DBA/2 mice Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice Animal models of virus-induced neurobehavioral sequelae: recent advances, methodological issues, and future prospects.Individual Differences in Male Rats in a Behavioral Test Battery: A Multivariate Statistical Approach Electrophysiological characterization of V2a interneurons and their locomotor-related activity in the neonatal mouse spinal cord.Unbridle biomedical research from the laboratory cage.Differences in mouse maternal care behavior - is there a genetic impact of the glucocorticoid receptor?Inhibitory avoidance learning in zebrafish (Danio rerio): effects of shock intensity and unraveling differences in task performance.Designing phenotyping studies for genetically engineered mice Behavioural phenotyping of casper mutant and 1-pheny-2-thiourea treated adult zebrafish.Impact of inherent variability and experimental parameters on the reliability of small animal PET data.Impact of temporal variation on design and analysis of mouse knockout phenotyping studies Remarkable changes in behavior and physiology of laboratory mice after the massive 2011 Tohoku earthquake in Japan.Where have I been? Where should I go? Spatial working memory on a radial arm maze in a rat model of depression.Environmental enrichment reduces the likelihood of alopecia in adult C57BL/6J mice.Reverse-translational biomarker validation of Abnormal Repetitive Behaviors in mice: an illustration of the 4P's modeling approach Making organisms model human behavior: situated models in North-American alcohol research, since 1950.Moist-heat resistance, spore aging, and superdormancy in Clostridium difficile Environmental enrichment of laboratory rodents: the answer depends on the question.Reversed light-dark cycle and cage enrichment effects on ethanol-induced deficits in motor coordination assessed in inbred mouse strains with a compact battery of refined tests.Synthetic biology's self-fulfilling prophecy--dangers of confinement from within and outside.Managing variation in the investigation of organismal development: problems and opportunities.Assessment of locomotion in chlorine exposed mice by computer vision and neural networks.Assessment of the Effects of 6 Standard Rodent Diets on Binge-Like and Voluntary Ethanol Consumption in Male C57BL/6J Mice Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests The Researchers' View of Scientific Rigor-Survey on the Conduct and Reporting of In Vivo Research.

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Environmental standardization: cure or cause of poor reproducibility in animal experiments?

http://www.wikidata.org/entity/Q37427393

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article científic

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scientific article published on April 2009

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Hanno Würbel

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Joseph P Garner

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S Helene Richter

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P2860

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades.

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments.

Different data from different labs: lessons from studies of gene-environment interaction.

Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive.

Exploiting human anatomical variability as a link between genome and cognome

Knockout mice: is it just genetics? Effect of enriched housing on fibulin-4(+/-) mice.

Animal definition: a necessity for the validity of animal experiments?

Genotype-environment interactions in mouse behavior: a way out of the problem.

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10.1038/NMETH.1312

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