Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
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Structural Maturation of HIV-1 Reverse Transcriptase-A Metamorphic Solution to Genomic InstabilityRibonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules.Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors.Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives.Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions.Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.Design, Synthesis, and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Anti-Inflammatory Agents.
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P2860
Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 20 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Exploiting drug-resistant enzy ...... ase-associated ribonuclease H.
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Exploiting drug-resistant enzy ...... ase-associated ribonuclease H.
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type
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Exploiting drug-resistant enzy ...... ase-associated ribonuclease H.
@en
Exploiting drug-resistant enzy ...... ase-associated ribonuclease H.
@nl
prefLabel
Exploiting drug-resistant enzy ...... ase-associated ribonuclease H.
@en
Exploiting drug-resistant enzy ...... ase-associated ribonuclease H.
@nl
P2093
P2860
P356
P1476
Exploiting drug-resistant enzy ...... ase-associated ribonuclease H.
@en
P2093
Graziella Tocco
Humeyra Taskent-Sezgin
Jason W Rausch
Jennifer A Wilson
John A Beutler
Pierluigi Caboni
Stuart F J Le Grice
Suhman Chung
Takashi Masaoka
P2860
P304
P356
10.1021/JM400405Z
P407
P577
2013-06-20T00:00:00Z