A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1
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The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependenceβ-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin.Transient receptor potential (TRP) channels: a clinical perspectiveA-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.PP2B/calcineurin-mediated desensitization of TRPV1 does not require AKAP150.Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors.Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat.A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphateChronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathwaysP2X₃ and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons.A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C.AKAP signaling complexes: pointing towards the next generation of therapeutic targets?The thermo-TRP ion channel family: properties and therapeutic implications.Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications.Transient receptor potential vanilloid 1 as a therapeutic target in analgesia.Molecular sensors and modulators of thermoreception.Modulation of nociceptive ion channels and receptors via protein-protein interactions: implications for pain relief.Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity.AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesiaA-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons.Long-Term Activation of Group I Metabotropic Glutamate Receptors Increases Functional TRPV1-Expressing Neurons in Mouse Dorsal Root Ganglia.Somatosensory scaffolding structures.Functional interactions between NMDA receptors and TRPV1 in trigeminal sensory neurons mediate mechanical hyperalgesia in the rat masseter muscle.Activation of NMDA receptors leads to phosphorylation of TRPV1 S800 by protein kinase C and A-Kinase anchoring protein 150 in rat trigeminal ganglia.Paclitaxel inhibits the activity and membrane localization of PKCα and PKCβI/II to elicit a decrease in stimulated calcitonin gene-related peptide release from cultured sensory neurons.Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.Identification of a signaling cascade that maintains constitutive δ-opioid receptor incompetence in peripheral sensory neurons.Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders.LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats.CRISPR Epigenome Editing of AKAP150 in DRG Neurons Abolishes Degenerative IVD-Induced Neuronal Activation.Phosphorylation regulates TRPV1 association with β-arrestin-2.AKAP150 mobilizes cPKC-dependent cardiac glucotoxicity.Serum response factor mediates nociceptor inflammatory pain plasticity.
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A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 September 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
A-kinase anchoring protein 150 ...... ion and sensitization of TRPV1
@en
A-kinase anchoring protein 150 ...... on and sensitization of TRPV1.
@nl
type
label
A-kinase anchoring protein 150 ...... ion and sensitization of TRPV1
@en
A-kinase anchoring protein 150 ...... on and sensitization of TRPV1.
@nl
prefLabel
A-kinase anchoring protein 150 ...... ion and sensitization of TRPV1
@en
A-kinase anchoring protein 150 ...... on and sensitization of TRPV1.
@nl
P2093
P2860
P1433
P1476
A-kinase anchoring protein 150 ...... ion and sensitization of TRPV1
@en
P2093
Amol M Patwardhan
Armen N Akopian
Mark S Shapiro
Michael A Henry
Nathaniel A Jeske
Nikita B Ruparel
P2860
P304
P356
10.1016/J.PAIN.2009.08.002
P407
P577
2009-09-19T00:00:00Z