Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligandFrom inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases.Membrane lipids and cell signaling.Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.A new trick for an old lipid.Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif.Design and Characterization of a Therapeutic Non-phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics To Promote Bone Formation.Lipid metabolism fattens up hedgehog signaling.Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.Contributions of Noncanonical Smoothened Signaling During Embryonic Development.Unravelling new pathways of sterol metabolism: lessons learned from in-born errors and cancer.G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.Lipids Alter Rhodopsin Function via Ligand-like and Solvent-like Interactions.Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancerRole of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic TargetsStructural Basis of Smoothened Activation in Hedgehog Signaling
P2860
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P2860
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 October 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cholesterol activates the G-pr ...... to promote Hedgehog signaling.
@en
Cholesterol activates the G-pr ...... to promote Hedgehog signaling.
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type
label
Cholesterol activates the G-pr ...... to promote Hedgehog signaling.
@en
Cholesterol activates the G-pr ...... to promote Hedgehog signaling.
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prefLabel
Cholesterol activates the G-pr ...... to promote Hedgehog signaling.
@en
Cholesterol activates the G-pr ...... to promote Hedgehog signaling.
@nl
P2093
P2860
P50
P356
P1433
P1476
Cholesterol activates the G-pr ...... to promote Hedgehog signaling
@en
P2093
Douglas F Covey
Giovanni Luchetti
Jennifer H Kong
Ria Sircar
Sigrid Nachtergaele
P2860
P356
10.7554/ELIFE.20304
P407
P577
2016-10-05T00:00:00Z