The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.

The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.

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http://www.wikidata.org/entity/Q37443338
The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myelomaEZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma.Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation.Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma.Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control.UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains.Evolutionary biology of high-risk multiple myeloma.The biological significance of histone modifiers in multiple myeloma: clinical applications
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.

Item
http://www.wikidata.org/entity/Q37443338
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 May 2016
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
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type
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
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prefLabel
The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
@en
The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
@en-gb
The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
@nl
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma
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P2860
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10.1158/1078-0432.CCR-15-1790
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P433
P478
P50
P5530
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P6179
P6366
P698
P932
P953