Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid. - Wikidata - wikimedia - TriplyDB

Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.

Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.

http://www.wikidata.org/entity/Q37446099

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Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives Nitro-fatty acids: novel anti-inflammatory lipid mediators Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartment.Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions.Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction.Protective effects of 10-nitro-oleic acid in a hypoxia-induced murine model of pulmonary hypertension Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male rats.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.Regulation of the mammalian heat shock factor 1.Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.Signaling actions of electrophiles: anti-inflammatory therapeutic candidates 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids.Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies.Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes Formation and signaling actions of electrophilic lipids Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses.Conjugated linoleic acid is a preferential substrate for fatty acid nitration.Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms.Protection of nitro-fatty acid against kidney diseases.Electrophilic nitro-fatty acids prevent astrocyte-mediated toxicity to motor neurons in a cell model of familial amyotrophic lateral sclerosis via nuclear factor erythroid 2-related factor activation Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine.Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice.Nitro-oleic acid protects against adriamycin-induced nephropathy in mice.Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans.New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy.Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity.Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species.Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

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Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.

http://www.wikidata.org/entity/Q37446099

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 05 October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Nrf2-dependent and -independen ...... activated by nitro-oleic acid.

@en

Nrf2-dependent and -independen ...... activated by nitro-oleic acid.

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type

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Nrf2-dependent and -independen ...... activated by nitro-oleic acid.

@en

Nrf2-dependent and -independen ...... activated by nitro-oleic acid.

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prefLabel

Nrf2-dependent and -independen ...... activated by nitro-oleic acid.

@en

Nrf2-dependent and -independen ...... activated by nitro-oleic acid.

@nl

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JBC.M109.064873

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Journal of Biological Chemistry

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Nrf2-dependent and -independen ...... activated by nitro-oleic acid.

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Anton J Horrevoets

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Bruce A Freeman

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Francisco J Schopfer

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Hanna Leinonen

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Henna-Kaisa Jyrkkänen

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Oscar L Volger

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Sanna-Kaisa Häkkinen

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Steven R Woodcock

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P2860

The GI-GPx gene is a target for Nrf2

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

Identifying differentially expressed genes using false discovery rate controlling procedures

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators

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33233-33241

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scholarly article

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10.1074/JBC.M109.064873

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284

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Seppo Ylä-Herttuala

Annukka M Kivelä

Emilia Kansanen

Anna-Liisa Levonen

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2009-10-05T00:00:00Z

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