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Computational Approaches for the Discovery of Human Proteasome Inhibitors: An OverviewIt Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer DiseaseThe Potential of Plant Phenolics in Prevention and Therapy of Skin DisordersMitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Role of advanced glycation end products in cellular signalingAutophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationProtein Oxidation in Aging: Does It Play a Role in Aging Progression?Targeting the ubiquitin-proteasome system in heart disease: the basis for new therapeutic strategiesA deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulationStructures of PHR Domains from Mus musculus Phr1 (Mycbp2) Explain the Loss-of-Function Mutation (Gly1092→Glu) of the C. elegans Ortholog RPM-1The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome SystemAging and immune function: molecular mechanisms to interventionsOxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signalingProteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiationPTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse.A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma.Carfilzomib: A new proteasome inhibitor for relapsed or refractory multiple myeloma.Intrinsic structural disorder confers cellular viability on oncogenic fusion proteinsOn to the road to degradation: atherosclerosis and the proteasomeA viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRsActivation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain.The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.Physiological regulation of Akt activity and stability.RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Changes in Activity and Kinetic Properties of the Proteasome in Different Rat Organs during Development and Maturation.An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myelomaUbiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implicationsSignaling and cytotoxic functions of 4-hydroxyalkenals.Cellular stress response pathways and ageing: intricate molecular relationshipsTargeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: a challenge for the future.Dynamic interactions between Bombyx mori nucleopolyhedrovirus and its host cells revealed by transcriptome analysisThe 19S proteasome activator promotes human cytomegalovirus immediate early gene expression through proteolytic and nonproteolytic mechanisms.Sex-related effects of reproduction on biomarkers of oxidative damage in free-living barn swallows (Hirundo rustica)Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradationLens fibre cell differentiation and organelle loss: many paths lead to clarity.Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts.Proteasome, but not autophagy, disruption results in severe eye and wing dysmorphia: a subunit- and regulator-dependent process in Drosophila.Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The proteasomal system.
@en
The proteasomal system.
@nl
type
label
The proteasomal system.
@en
The proteasomal system.
@nl
prefLabel
The proteasomal system.
@en
The proteasomal system.
@nl
P1476
The proteasomal system
@en
P2093
Betül Catalgol
P304
P356
10.1016/J.MAM.2009.04.001
P577
2009-04-14T00:00:00Z