Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma.
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A Metabolic Immune Checkpoint: Adenosine in Tumor MicroenvironmentMyeloid cells in the tumor microenvironment: Role of adenosineProbing biased/partial agonism at the G protein-coupled A(2B) adenosine receptor.Big opportunities for small molecules in immuno-oncology.Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression.Transcriptional regulation of myeloid-derived suppressor cells.Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma modelTargeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor CellsTrial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy.Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma modelTargeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer.Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment.CD73-adenosine: a next-generation target in immuno-oncology.Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation.A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation.Extracellular purines, purinergic receptors and tumor growth.A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer.Galectin-1 inhibits oral-intestinal allergy syndrome.Targeting A2 adenosine receptors in cancer.Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer.The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets.Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection.Targeting the adenosine A2b receptor in the tumor microenvironment overcomes local immunosuppression by myeloid-derived suppressor cells.Targeting immunosuppressive adenosine in cancer.Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages.Inflammatory Cytokine Pattern Is Sex-Dependent in Mouse Cutaneous Melanoma Experimental Model.The Hypoxia-Adenosine Link during Intestinal Inflammation.Hypoxia-Driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression.Targeting the Adenosinergic Axis in Chronic Lymphocytic Leukemia: A Way to Disrupt the Tumor Niche?CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer.
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Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Blockade of A2b adenosine rece ...... in a mouse model of melanoma.
@en
Blockade of A2b adenosine rece ...... in a mouse model of melanoma.
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type
label
Blockade of A2b adenosine rece ...... in a mouse model of melanoma.
@en
Blockade of A2b adenosine rece ...... in a mouse model of melanoma.
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prefLabel
Blockade of A2b adenosine rece ...... in a mouse model of melanoma.
@en
Blockade of A2b adenosine rece ...... in a mouse model of melanoma.
@nl
P2093
P2860
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Blockade of A2b adenosine rece ...... s in a mouse model of melanoma
@en
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Aldo Pinto
Piera Maiolino
Raffaella Iannone
Silvana Morello
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P304
P356
10.1593/NEO.131748
P50
P577
2013-12-01T00:00:00Z