Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis
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The complex molecular biology of amyotrophic lateral sclerosis (ALS)Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants.Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.The structural biochemistry of the superoxide dismutases.Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis.Isolating toxic insulin amyloid reactive species that lack β-sheets and have wide pH stabilityBiochemical properties and in vivo effects of the SOD1 zinc-binding site mutant (H80G)Screening preeclamptic cord plasma for proteins associated with decreased breast cancer susceptibility.Metal-deficient SOD1 in amyotrophic lateral sclerosis.Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALSThe Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation.BODIPY-Based Fluorescent Probes for Sensing Protein Surface-Hydrophobicity.Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.Cellular Redox Systems Impact the Aggregation of Cu,Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis.Insights into the mechanisms of copper dyshomeostasis in amyotrophic lateral sclerosis.Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity.Increased hydrophobic surface exposure in the cataract-related G18V variant of human γS-crystallin.Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?The Role of Metal Binding in the Amyotrophic Lateral Sclerosis-Related Aggregation of Copper-Zinc Superoxide Dismutase.Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review.
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P2860
Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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name
Metal deficiency increases abe ...... amyotrophic lateral sclerosis
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Metal deficiency increases abe ...... amyotrophic lateral sclerosis.
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type
label
Metal deficiency increases abe ...... amyotrophic lateral sclerosis
@en
Metal deficiency increases abe ...... amyotrophic lateral sclerosis.
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prefLabel
Metal deficiency increases abe ...... amyotrophic lateral sclerosis
@en
Metal deficiency increases abe ...... amyotrophic lateral sclerosis.
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P2093
P2860
P356
P1476
Metal deficiency increases abe ...... amyotrophic lateral sclerosis
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C Robert Matthews
Joan Selverstone Valentine
Lawrence J Hayward
Osman Bilsel
P John Hart
Sai V Seetharaman
Se Hui Sohn
P2860
P304
27746-27758
P356
10.1074/JBC.M109.043729
P407
P577
2009-08-03T00:00:00Z