Prevention of genital herpes simplex virus type 1 and 2 disease in mice immunized with a gD-expressing dominant-negative recombinant HSV-1.
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Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs.A herpes simplex virus 2 (HSV-2) glycoprotein D-expressing nonreplicating dominant-negative HSV-2 virus vaccine is superior to a gD2 subunit vaccine against HSV-2 genital infection in guinea pigsA single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.Development of a glycoprotein D-expressing dominant-negative and replication-defective herpes simplex virus 2 (HSV-2) recombinant viral vaccine against HSV-2 infection in miceImmunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2A Herpes Simplex Virus 2 (HSV-2) gD Mutant Impaired for Neural Tropism Is Superior to an HSV-2 gD Subunit Vaccine To Protect Animals from Challenge with HSV-2.The challenge of developing a herpes simplex virus 2 vaccine.Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections.Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responsesHSV Recombinant Vectors for Gene Therapy.Development of Recombinant HSV-Based Vaccine Vectors.
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Prevention of genital herpes simplex virus type 1 and 2 disease in mice immunized with a gD-expressing dominant-negative recombinant HSV-1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Prevention of genital herpes s ...... nt-negative recombinant HSV-1.
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Prevention of genital herpes s ...... nt-negative recombinant HSV-1.
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type
label
Prevention of genital herpes s ...... nt-negative recombinant HSV-1.
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Prevention of genital herpes s ...... nt-negative recombinant HSV-1.
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prefLabel
Prevention of genital herpes s ...... nt-negative recombinant HSV-1.
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Prevention of genital herpes s ...... nt-negative recombinant HSV-1.
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Prevention of genital herpes s ...... nt-negative recombinant HSV-1.
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Natali V Akhrameyeva
Richard Brans
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10.1038/JID.2009.86
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2009-04-09T00:00:00Z
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P6179
1050328859