Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4. - Wikidata - wikimedia - TriplyDB

Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4.

Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4.

http://www.wikidata.org/entity/Q37454403

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Development of a unique small molecule modulator of CXCR4 Hydrogen bond strengths in phosphorylated and sulfated amino acid residues NMR as a tool to investigate the structure, dynamics and function of membrane proteins.i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.Elucidating a key component of cancer metastasis: CXCL12 (SDF-1α) binding to CXCR4.CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells.Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design Emerging concepts and approaches for chemokine-receptor drug discovery.Chemokine receptor oligomerization and allostery.Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification.Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3 Structure and function of G protein-coupled receptors using NMR spectroscopy.Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.Structural NMR of protein oligomers using hybrid methods.Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine.Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation.The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions.Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies.Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy.Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction.Inhibition of metastasis of rhabdomyosarcoma by a novel neutralizing antibody to CXC chemokine receptor-4.Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR.5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype.NMR in the Analysis of Functional Chemokine Interactions and Drug Discovery Structural perspectives on antimicrobial chemokines.Quantitatively resolving multivalent interactions on a macroscopic scale using force spectroscopy.Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes.Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery.Human β-defensin-3 structure motifs that are important in CXCR4 antagonism Structural basis of ligand interaction with atypical chemokine receptor 3.Structural Basis of Native CXCL7 Monomer Binding to CXCR2 Receptor N-Domain and Glycosaminoglycan Heparin Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function Pharmacological modulation of chemokine receptor function.Chemokine receptor modeling: an interdisciplinary approach to drug design.Cross-saturation and transferred cross-saturation experiments.

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Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4.

http://www.wikidata.org/entity/Q37454403

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Structural basis of the intera ...... rotein-coupled receptor CXCR4.

@en

Structural basis of the intera ...... rotein-coupled receptor CXCR4.

@nl

type

label

Structural basis of the intera ...... rotein-coupled receptor CXCR4.

@en

Structural basis of the intera ...... rotein-coupled receptor CXCR4.

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prefLabel

Structural basis of the intera ...... rotein-coupled receptor CXCR4.

@en

Structural basis of the intera ...... rotein-coupled receptor CXCR4.

@nl

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JBC.M109.024851

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Journal of Biological Chemistry

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Structural basis of the intera ...... protein-coupled receptor CXCR4

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Chie Yoshiura

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Hideo Takahashi

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Hiroaki Terasawa

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Ichio Shimada

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Kouji Matsushima

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Masako Hirose

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Sae Tominaga

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Takahiro Hirai

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Takumi Ueda

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Yoshitake Maeda

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

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Involvement of chemokine receptors in breast cancer metastasis

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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10.1074/JBC.M109.024851

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284

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2009-10-18T00:00:00Z

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19837984

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G protein-coupled receptor

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