Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.
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Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsA tyrosine residue on the TSH receptor stabilizes multimer formationDominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys.Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSHExtended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain.Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies.Production, purification, and characterization of recombinant hFSH glycoforms for functional studies.Naturally Occurring Follicle-Stimulating Hormone Glycosylation Variants.Trafficking of the follitropin receptor.Revisiting and questioning functional rescue between dimerized LH receptor mutants.Biological Significance of GPCR Heteromerization in the Neuro-Endocrine SystemMapping the follicle-stimulating hormone-induced signaling networks.Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone StimulationHeterodimerization between the lutropin and follitropin receptors is associated with an attenuation of hormone-dependent signaling.Novel insights on thyroid-stimulating hormone receptor signal transduction.Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24)).The roles played by highly truncated splice variants of G protein-coupled receptors.Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor.From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).Intracellular Trafficking of Gonadotropin Receptors in Health and Disease.Temporal reprogramming of calcium signalling via crosstalk of gonadotrophin receptors that associate as functionally asymmetric heteromers.
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Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Structural determinants underl ...... d human follitropin receptors.
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Structural determinants underl ...... d human follitropin receptors.
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type
label
Structural determinants underl ...... d human follitropin receptors.
@en
Structural determinants underl ...... d human follitropin receptors.
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Structural determinants underl ...... d human follitropin receptors.
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Structural determinants underl ...... d human follitropin receptors.
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P2093
P2860
P1433
P1476
Structural determinants underl ...... d human follitropin receptors.
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P2093
Deborah L Segaloff
Meilin Zhang
Rongbin Guan
Terence E Hébert
Xiuyan Feng
Xueqing Wu
P2860
P304
P356
10.1016/J.CELLSIG.2009.09.023
P577
2009-09-30T00:00:00Z