Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.
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The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavAdverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machinesMeasuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves.A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of SykFast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscopeTumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo.In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymersProtein arginine methyltransferase 6 regulates multiple aspects of gene expression.Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.SYK allelic loss and the role of Syk-regulated genes in breast cancer survival.Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Cortactin: a multifunctional regulator of cellular invasivenessNanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.Targeting a cell state common to triple-negative breast cancersSensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice.Regulation of adherens junction dynamics by phosphorylation switches.Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells.CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunitModulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.Alternative splicing of spleen tyrosine kinase differentially regulates colorectal cancer progression.DNA methylation and breast tumor clinicopathological features: The Western New York Exposures and Breast Cancer (WEB) studySyk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion.Expression of variant isoforms of the tyrosine kinase SYK determines the prognosis of hepatocellular carcinoma.Cortactin in cell migration and cancer at a glanceSpleen Tyrosine Kinase Modulates Fibrous Airway Obliteration and Associated Lymphoid Neogenesis After Transplantation.Downregulation of spleen tyrosine kinase in hepatocellular carcinoma by promoter CpG island hypermethylation and its potential role in carcinogenesis.Adherens Junction and E-Cadherin complex regulation by epithelial polarity.Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors.Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells.Bioinformatics analysis of gene expression data for the identification of critical genes in breast invasive carcinoma.Syk is low-expressed in non-small-cell lung cancer and inversely correlates with patient's survival.Cortactin in cancer cell migration and invasion.Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors.Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway.Lysophosphatidic acid (LPA) stimulates mouse mammary epithelial cell growth.Prognostic value of spleen tyrosine kinase in human solid tumors.
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Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of the protein tyrosine k ...... tility in breast cancer cells.
@en
Role of the protein tyrosine k ...... tility in breast cancer cells.
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type
label
Role of the protein tyrosine k ...... tility in breast cancer cells.
@en
Role of the protein tyrosine k ...... tility in breast cancer cells.
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prefLabel
Role of the protein tyrosine k ...... tility in breast cancer cells.
@en
Role of the protein tyrosine k ...... tility in breast cancer cells.
@nl
P2093
P2860
P1476
Role of the protein tyrosine k ...... otility in breast cancer cells
@en
P2093
Bethany M Alicie
Ulka Shrikhande
Xiaoying Zhang
P2860
P304
P356
10.1158/1541-7786.MCR-08-0371
P577
2009-05-12T00:00:00Z