Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

http://www.wikidata.org/entity/Q37463481

about

Alzheimer mechanisms and therapeutic strategies RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction p53 opens the mitochondrial permeability transition pore to trigger necrosis Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.Novel therapeutics for Alzheimer's disease: an update Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease Mitochondria, calcium and cell death: a deadly triad in neurodegeneration Mitochondria-associated ER membranes and Alzheimer disease The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease Alterations in Mitochondrial Quality Control in Alzheimer's Disease Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide Molecular mechanisms that differentiate apoptosis from programmed necrosis Mitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's Diseases Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease Mitochondrial permeability transition pore is a potential drug target for neurodegeneration Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea High-resolution crystal structures of two crystal forms of human cyclophilin D in complex with PEG 400 molecules Ubiquitin-dependent mitochondrial protein degradation.Vitamin A and Retinoids as Mitochondrial Toxicants Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains The proteome response to amyloid protein expression in vivo Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway Isoform-specific inhibition of cyclophilins The sour side of neurodegenerative disorders: the effects of protein glycation.Bmi1 regulates auditory hair cell survival by maintaining redox balance.Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.Mitochondrial superoxide: a key player in Alzheimer's disease Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.Unlocking the Door to Neuronal Woes in Alzheimer's Disease: Aβ and Mitochondrial Permeability Transition Pore The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice Identification of human ABAD inhibitors for rescuing Aβ-mediated mitochondrial dysfunction.

P2860

Q22252311-599AC9EE-94DE-46CC-A9D6-2BB319B03CC9 Q24315809-986CFF9B-6D7C-440F-B189-C98036497A1A Q24338796-8F7D4390-28A2-47AB-A0B2-FAF8C2B065F7 Q24598637-377FED5C-3B84-48FD-97B6-534A2C0743B1 Q24620383-7038EBC5-85E2-4750-9EEA-285F77C8FF0A Q24642355-9CA7F5BF-E747-41F1-A576-85595C432031 Q24646020-E6E93BD6-5AAA-47F7-A2AC-E3DC2BCC2BD8 Q26745495-3243507B-8C0A-4F40-86A4-A688326A9339 Q26749074-1B355C7F-662D-4751-880F-FD8904C8A3B7 Q26765824-B6E3DD6D-D9EB-406B-ADFB-C6C01C8E394A Q26768215-175447FD-AD78-4A0F-8B11-FA07A9CC2B93 Q26823798-1D490C01-566D-4920-AE0E-3956BAE3C47A Q26824520-547E8CB1-8A4B-4605-ACC6-A81736AFE9EE Q26829092-5932B797-6CB1-4DE1-A044-EDFEE6058141 Q26859141-416784C5-D3EE-4987-86C3-9CC9EA8A6BD9 Q27012950-C51B5ED9-2151-439B-A21D-6E4F97B7FFF1 Q27023850-DFD32615-BF05-4D24-BE9E-8F6595F39FC9 Q27313741-39A930EF-42FC-41F7-9447-5B67F57BA6E8 Q27318046-884C29AB-4BDA-412C-A00F-DF2A06D4735F Q27328992-0201147D-B874-423C-825B-4368D905AD1F Q27684278-54FCA880-F2B6-4A46-90AB-8ACE83E1CE86 Q27692704-038BFC3B-1725-493E-8118-E3401EE060A6 Q28081121-1F774968-88EA-47F1-AC7C-764CCBC3A182 Q28392337-1A23AC60-AA0B-44C0-B0E7-00A0CB414F81 Q28485287-102D6D63-CE62-4DBB-BEAC-A31EEA7B278D Q28509251-6B7E2B92-2403-44B9-8C32-97A8DA1499C3 Q28551172-84D570CC-5E3C-4D6C-8A2F-972998FD2B34 Q30319101-B19EA2AF-4913-4602-A021-B5AABD1DEFAE Q30386079-D627519D-7171-48BC-A2A8-83FA67FD96CE Q30396588-D71F0481-2DD0-4A3F-9689-CAC4AB388FAC Q30476347-37FFAF92-1F56-4753-B73F-9024AD3F49BD Q30483386-6243B1E1-91B7-492D-BF42-C58204295F47 Q30493579-A3BD9A3A-F3DB-4FFA-A92C-1FE4D067EA3B Q33585950-911001E4-7B9B-43D0-A52D-C39E6C5EA630 Q33627865-BDA853EB-B5E7-4A74-A950-D54C386ADE2E Q33639466-40F5FEAD-873C-47E2-9489-3B69F98BF980 Q33652882-BB62B5F6-10A3-4F48-B740-44DDE2A409F5 Q33664175-9501F559-70EE-4CDB-9F08-E7810EA49F6E Q33715954-75B70703-F3C6-41BC-94B8-ABB2DBF32FE2 Q33850211-90CCB3A8-742D-46E7-A835-63E97DB12AF9

P2860

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

http://www.wikidata.org/entity/Q37463481

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 21 September 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Cyclophilin D deficiency atten ...... memory in Alzheimer's disease.

@en

Cyclophilin D deficiency atten ...... memory in Alzheimer's disease.

@nl

type

label

Cyclophilin D deficiency atten ...... memory in Alzheimer's disease.

@en

Cyclophilin D deficiency atten ...... memory in Alzheimer's disease.

@nl

prefLabel

Cyclophilin D deficiency atten ...... memory in Alzheimer's disease.

@en

Cyclophilin D deficiency atten ...... memory in Alzheimer's disease.

@nl

P1433

Q37463481-F37F7373-7642-49A8-9C1B-4ED9FB8A53F8

P1476

Q37463481-FEACE79D-C275-4A03-BA9D-119DA4EA4952

P2093

Q37463481-12A14183-AD1F-4F9B-9DEB-50B11DF8D2F8

Q37463481-2D33C5AF-5E2B-4409-B826-9FB8838E2D7F

Q37463481-4E4D22DB-A9BD-4B70-AFC0-D791E403A159

Q37463481-9985B5BF-F472-4A69-9726-206AC387A08C

Q37463481-9B5EB270-10C4-41AC-87AA-AB7367E2AA7F

Q37463481-A092F347-CEC8-4F16-B0FD-B598BE266ADE

Q37463481-B25FA6C8-225D-43C6-9EAE-05BD6301776C

Q37463481-BF892992-06FB-430E-AC7B-1419C296DC3C

Q37463481-BFAA7AD4-C25C-4BDF-8616-90D0579060BD

Q37463481-CDED740B-8777-4F1E-A625-67A6F2BB6A6E

P2860

Q37463481-0AC634EB-9B2F-428F-83B0-C54D3D2F9D93

Q37463481-13223CBB-ABD3-4034-B19A-BC13EF8A5B44

Q37463481-19B4B55A-DCFA-45CD-9A2D-7C9FC7D25E55

Q37463481-1D94144E-2B9A-49D7-A987-6F6DE3832844

Q37463481-1FF127EF-E3D7-42CF-B567-D0922750007D

Q37463481-241F922C-226A-48A6-BF80-7D607B7D1B01

Q37463481-2DB16AC7-1C03-4FCD-B30F-B548DDEA5385

Q37463481-3049B2CA-3451-470E-B555-D211657D3B50

Q37463481-34B0935F-7BB6-4BEA-B017-1B0CDFFB75B4

Q37463481-448C6069-44B5-4F13-A515-7DBC9A9D86E5

P2888

Q37463481-08EEC5F9-66D1-4609-AD45-50215A32BD6F

P304

Q37463481-1669E95F-582D-495F-A6C3-1641AF825434

P31

Q37463481-15D2756C-E05F-4817-AD0A-CC39870F2476

P356

Q37463481-DF34C348-C1CB-4ECB-A0DB-C892810B3B05

P407

Q37463481-8B1FC701-4B4E-4263-A225-DE9DC74B1B3D

P433

Q37463481-63236A0B-9DDC-40DD-9D79-7D9C37633746

P478

Q37463481-0BBF4F4B-4261-4036-80D2-FA2634BCBE64

P50

Q37463481-164D2D6B-2D73-4C80-812B-D5563120B28E

Q37463481-5FCB2C18-1280-4E7F-A46D-AE072613E10C

Q37463481-6B28A33A-9441-4579-BB0E-F815E01DB3CF

P577

Q37463481-EA997551-87B5-44C1-8C75-BFE68BD0C4E6

P5875

Q37463481-C3FBFF28-809D-46F0-9809-BBF559C4F4C9

P698

Q37463481-11C84867-CCEB-4F99-95FF-6B1C57DF3B58

P921

Q37463481-D7A7CF1C-E12D-4F24-9E8B-1400A9C52646

Q37463481-E84F5B3D-AF3E-4EB1-BC45-89FB95D005C0

P932

Q37463481-CB7C070A-7D10-4ABE-B147-2F9122DE34F4

P356

P1433

Nature Medicine

P1476

Cyclophilin D deficiency atten ...... memory in Alzheimer's disease.

@en

P2093

Alexander A Sosunov

http://www.w3.org/2001/XMLSchema#string

Chunyu Wang

http://www.w3.org/2001/XMLSchema#string

Doris Chen

http://www.w3.org/2001/XMLSchema#string

Fang Fang

http://www.w3.org/2001/XMLSchema#string

Guy M McKhann

http://www.w3.org/2001/XMLSchema#string

Heng Du

http://www.w3.org/2001/XMLSchema#string

Hong Zhang

http://www.w3.org/2001/XMLSchema#string

Jean Paul Vonsattel

http://www.w3.org/2001/XMLSchema#string

John Xi Chen

http://www.w3.org/2001/XMLSchema#string

Lan Guo

http://www.w3.org/2001/XMLSchema#string

P2860

Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease.

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics.

Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore.

Cyclophilins and their possible role in the stress response.

The mitochondrial spiral. An adequate cause of dementia in the Alzheimer's syndrome.

P2888

P304

1097-1105

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NM.1868

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

14

http://www.w3.org/2001/XMLSchema#string

P50

Jeffery D. Molkentin

Ottavio Arancio

Frank J. Gunn-Moore

P577

2008-09-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23270140

http://www.w3.org/2001/XMLSchema#string

P698

18806802

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

2789841

http://www.w3.org/2001/XMLSchema#string