Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.
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Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.A non-canonical binding interface in the crystal structure of HIV-1 gp120 core in complex with CD4Plasticity and Epitope Exposure of the HIV-1 Envelope Trimer.Antibody Functional Assays as Measures of Fc Receptor-Mediated Immunity to HIV - New Technologies and their Impact on the HIV Vaccine Field.How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.Development of an HIV vaccine using a vesicular stomatitis virus vector expressing designer HIV-1 envelope glycoproteins to enhance humoral responses.HIV-1 Cross-reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Non-human Primate.Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.Conformational Heterogeneity of the HIV Envelope Glycan Shield.Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes.X-ray and EM structures of a natively glycosylated HIV-1 envelope trimer.The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.Antimicrobial peptide capsids of de novo design.Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region.Identification of novel structural determinants in MW965 Env that regulate the neutralization phenotype and conformational masking potential of primary HIV-1 isolates.Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages.Recent advances in retroviruses via cryo-electron microscopy.HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers.Structural Insights from HIV-Antibody Coevolution and Related Immunization StudiesCommon helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virionsDEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions
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Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.
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article científic
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artigo científico
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bilimsel makale
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scientific article published on 31 October 2016
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vedecký článok
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Cryo-EM structure of a CD4-bou ...... ements of the gp120 V1V2 loop.
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Cryo-EM structure of a CD4-bou ...... ements of the gp120 V1V2 loop.
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Cryo-EM structure of a CD4-bou ...... ements of the gp120 V1V2 loop.
@en
Cryo-EM structure of a CD4-bou ...... ements of the gp120 V1V2 loop.
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prefLabel
Cryo-EM structure of a CD4-bou ...... ements of the gp120 V1V2 loop.
@en
Cryo-EM structure of a CD4-bou ...... ements of the gp120 V1V2 loop.
@nl
P2093
P2860
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P1476
Cryo-EM structure of a CD4-bou ...... ements of the gp120 V1V2 loop.
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Alexander A Cohen
Grant J Jensen
Haoqing Wang
Harry B Gristick
Rachel P Galimidi
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P304
E7151-E7158
P356
10.1073/PNAS.1615939113
P407
P577
2016-10-31T00:00:00Z