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Chloride channel-targeted therapy for secretory diarrheas

Chloride channel-targeted therapy for secretory diarrheas

http://www.wikidata.org/entity/Q37472982

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Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.Bioactivity-guided fractionation of an antidiarrheal Chinese herb Rhodiola kirilowii (Regel) Maxim reveals (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate as inhibitors of cystic fibrosis transmembrane conductance regulator.Targeting Small Bowel Receptors to Treat Constipation and Diarrhea.Cytokine responses and epithelial function in the intestinal mucosa.Individualized medicine using intestinal responses to CFTR potentiators and correctors.CFTR pharmacology.Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea.Targeting and alteration of tight junctions by bacteria and their virulence factors such as Clostridium perfringens enterotoxin.CFTR reduces microtubule-dependent Campylobacter jejuni invasion.Development of arrayed colonic organoids for screening of secretagogues associated with enterotoxins.

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Chloride channel-targeted therapy for secretory diarrheas

http://www.wikidata.org/entity/Q37472982

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 27 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Chloride channel-targeted therapy for secretory diarrheas

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Chloride channel-targeted therapy for secretory diarrheas.

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type

label

Chloride channel-targeted therapy for secretory diarrheas

@en

Chloride channel-targeted therapy for secretory diarrheas.

@nl

prefLabel

Chloride channel-targeted therapy for secretory diarrheas

@en

Chloride channel-targeted therapy for secretory diarrheas.

@nl

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J.COPH.2013.08.005

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Current Opinion in Pharmacology

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Chloride channel-targeted therapy for secretory diarrheas

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A S Verkman

http://www.w3.org/2001/XMLSchema#string

Jay R Thiagarajah

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P2860

Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions

Distribution of ClC-2 chloride channel in rat and human epithelial tissues

Global burden of childhood pneumonia and diarrhoea

Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system

Prolonged episodes of acute diarrhea reduce growth and increase risk of persistent diarrhea in children.

Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels

Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion.

The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon

CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures.

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888-894

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scholarly article

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10.1016/J.COPH.2013.08.005

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6

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13

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2013-08-27T00:00:00Z

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23992767

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Afọ ọsịsa

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3890324

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