Chloride channel-targeted therapy for secretory diarrheas
about
Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging TreatmentsPGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.Bioactivity-guided fractionation of an antidiarrheal Chinese herb Rhodiola kirilowii (Regel) Maxim reveals (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate as inhibitors of cystic fibrosis transmembrane conductance regulator.Targeting Small Bowel Receptors to Treat Constipation and Diarrhea.Cytokine responses and epithelial function in the intestinal mucosa.Individualized medicine using intestinal responses to CFTR potentiators and correctors.CFTR pharmacology.Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea.Targeting and alteration of tight junctions by bacteria and their virulence factors such as Clostridium perfringens enterotoxin.CFTR reduces microtubule-dependent Campylobacter jejuni invasion.Development of arrayed colonic organoids for screening of secretagogues associated with enterotoxins.
P2860
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P2860
Chloride channel-targeted therapy for secretory diarrheas
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 August 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Chloride channel-targeted therapy for secretory diarrheas
@en
Chloride channel-targeted therapy for secretory diarrheas.
@nl
type
label
Chloride channel-targeted therapy for secretory diarrheas
@en
Chloride channel-targeted therapy for secretory diarrheas.
@nl
prefLabel
Chloride channel-targeted therapy for secretory diarrheas
@en
Chloride channel-targeted therapy for secretory diarrheas.
@nl
P2860
P1476
Chloride channel-targeted therapy for secretory diarrheas
@en
P2093
A S Verkman
Jay R Thiagarajah
P2860
P304
P356
10.1016/J.COPH.2013.08.005
P577
2013-08-27T00:00:00Z