Sprouty proteins: modified modulators, matchmakers or missing links?
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Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsRaf family kinases: old dogs have learned new tricksTargeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or functionProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesAdditional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB DomainNegative feedback regulation of the ERK1/2 MAPK pathwayCooperative and independent functions of FGF and Wnt signaling during early inner ear development.The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.Identification of new genetic risk variants for type 2 diabetes.Next-generation sequencing identifies rare variants associated with Noonan syndromeSprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation.Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signalingErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cellsThe Fibroblast Growth Factor signaling pathwaySprouty2 downregulates angiogenesis during mouse skin wound healing.Pathways driving the endocytosis of mutant and wild-type EGFR in cancer.Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signalingInactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalizationSprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats.Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinomaHIV Assembly and Budding: Ca(2+) Signaling and Non-ESCRT Proteins Set the Stage.Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways.Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levels.Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction.A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.Initial report on differential expression of sprouty proteins 1 and 2 in human epithelial ovarian cancer cell lines.Inhibition of Sprouty2 polarizes macrophages toward an M2 phenotype by stimulation with interferon γ and Porphyromonas gingivalis lipopolysaccharide.Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.Sprouty 2 binds ESCRT-II factor Eap20 and facilitates HIV-1 gag release.Prediction of novel genes associated with negative regulators of toll-like receptors-induced inflammation based on endotoxin tolerance.
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Sprouty proteins: modified modulators, matchmakers or missing links?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 07 May 2009
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Sprouty proteins: modified modulators, matchmakers or missing links?
@en
Sprouty proteins: modified modulators, matchmakers or missing links?
@nl
type
label
Sprouty proteins: modified modulators, matchmakers or missing links?
@en
Sprouty proteins: modified modulators, matchmakers or missing links?
@nl
prefLabel
Sprouty proteins: modified modulators, matchmakers or missing links?
@en
Sprouty proteins: modified modulators, matchmakers or missing links?
@nl
P2093
P356
P1476
Sprouty proteins: modified modulators, matchmakers or missing links?
@en
P2093
P304
P356
10.1677/JOE-09-0110
P407
P577
2009-05-07T00:00:00Z