Conformational changes associated with proton-dependent gating of ASIC1a.
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Structure and activity of the acid-sensing ion channelsThe contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking.Insights into the mechanism of pore opening of acid-sensing ion channel 1a.Second transmembrane domain modulates epithelial sodium channel gating in response to shear stressENaC structure and function in the wake of a resolved structure of a family member.Computational Tools for Interpreting Ion Channel pH-Dependence.Contribution of residues in second transmembrane domain of ASIC1a protein to ion selectivity.Role of the wrist domain in the response of the epithelial sodium channel to external stimuli.Gating transitions in the palm domain of ASIC1a.Structural mechanisms underlying the function of epithelial sodium channel/acid-sensing ion channel.The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization.Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.Independent contribution of extracellular proton binding sites to ASIC1a activation.Protonation controls ASIC1a activity via coordinated movements in multiple domains.Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.Patch-clamp fluorometry: electrophysiology meets fluorescence.ASICs and neuropeptides.Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells.Asn415 in the beta11-beta12 linker decreases proton-dependent desensitization of ASIC1.Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels.
P2860
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P2860
Conformational changes associated with proton-dependent gating of ASIC1a.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conformational changes associated with proton-dependent gating of ASIC1a.
@en
Conformational changes associated with proton-dependent gating of ASIC1a.
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type
label
Conformational changes associated with proton-dependent gating of ASIC1a.
@en
Conformational changes associated with proton-dependent gating of ASIC1a.
@nl
prefLabel
Conformational changes associated with proton-dependent gating of ASIC1a.
@en
Conformational changes associated with proton-dependent gating of ASIC1a.
@nl
P2093
P2860
P356
P1476
Conformational changes associated with proton-dependent gating of ASIC1a.
@en
P2093
Christopher J Passero
Marcelo D Carattino
Sora Okumura
P2860
P304
36473-36481
P356
10.1074/JBC.M109.055418
P407
P577
2009-10-26T00:00:00Z