Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
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Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administrationSystematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasisPharmacokinetics of artesunate alone and in combination with sulfadoxine/pyrimethamine in healthy Sudanese volunteersArtemisone effective against murine cerebral malariaArtemether combined with shRNA interference of vascular cell adhesion molecule-1 significantly inhibited the malignant biological behavior of human glioma cells.Orally formulated artemisinin in healthy fasting Vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover studyPharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.Artesunate Protected Blood-Brain Barrier via Sphingosine 1 Phosphate Receptor 1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats.Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoformsAnticancer activities of artemisinin and its bioactive derivatives.Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway.Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.Highly active ozonides selected against drug resistant malariaContribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate.An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.Artesunate inhibits proliferation of naïve CD4(+) T cells but enhances function of effector T cells.Stability and antiviral activity against human cytomegalovirus of artemisinin derivatives.The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone.
P2860
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P2860
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
@en
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
@nl
type
label
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
@en
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
@nl
prefLabel
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
@en
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
@nl
P2093
P1476
Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.
@en
P2093
Anirudh Gautam
Jyoti Paliwal
Tausif Ahmed
Vijay Batra
P304
P356
10.2174/138920009787846323
P407
P577
2009-03-01T00:00:00Z