HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. - Wikidata - wikimedia - TriplyDB

HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.

HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.

http://www.wikidata.org/entity/Q37484581

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The role of HDAC6 in cancer Enhancement of stress resilience through histone deacetylase 6-mediated regulation of glucocorticoid receptor chaperone dynamics.Emerging data on androgen receptor splice variants in prostate cancer HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience.Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression.Minireview: The versatile roles of lysine deacetylases in steroid receptor signaling SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells.The N-terminal domain of the androgen receptor drives its nuclear localization in castration-resistant prostate cancer cells Bioinformatic analysis and post-translational modification crosstalk prediction of lysine acetylation.Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients Glucocorticoid receptor cofactors as therapeutic targets.Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.Minireview: Alternative activation pathways for the androgen receptor in prostate cancer.Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells Berberine suppresses androgen receptor signaling in prostate cancer.Post-translational modifications of Hsp90 and their contributions to chaperone regulation Epigenetics in prostate cancer.Structure-based virtual screening and identification of a novel androgen receptor antagonist.Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression.Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression HDAC6 and ovarian cancer.CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention.Selectively targeting prostate cancer with antiandrogen equipped histone deacetylase inhibitors.Gene Expression Profiling Reveals Regulation of ERK Phosphorylation by Androgen-Induced Tumor Suppressor U19/EAF2 in the Mouse Prostate.Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy.Heat shock proteins in prostate cancer: from tumorigenesis to the clinic.Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells.Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer.Histone H1 expression in human prostate cancer tissues and cell lines.Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance.N-terminal domain of the androgen receptor contains a region that can promote cytoplasmic localization.Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells.Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90.Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.Beyond androgen deprivation: ancillary integrative strategies for targeting the androgen receptor addiction of prostate cancer.LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals.

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HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.

http://www.wikidata.org/entity/Q37484581

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 23 October 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

HDAC6 regulates androgen recep ...... ion-resistant prostate cancer.

@en

HDAC6 regulates androgen recep ...... ion-resistant prostate cancer.

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type

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HDAC6 regulates androgen recep ...... ion-resistant prostate cancer.

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HDAC6 regulates androgen recep ...... ion-resistant prostate cancer.

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HDAC6 regulates androgen recep ...... ion-resistant prostate cancer.

@en

HDAC6 regulates androgen recep ...... ion-resistant prostate cancer.

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Molecular Endocrinology

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HDAC6 regulates androgen recep ...... ion-resistant prostate cancer.

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Javid A Dar

http://www.w3.org/2001/XMLSchema#string

Joel B Nelson

http://www.w3.org/2001/XMLSchema#string

June Liu

http://www.w3.org/2001/XMLSchema#string

Junkui Ai

http://www.w3.org/2001/XMLSchema#string

Lingqi Liu

http://www.w3.org/2001/XMLSchema#string

Yujuan Wang

http://www.w3.org/2001/XMLSchema#string

Zhou Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning and characterization of a novel histone deacetylase HDAC10

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling

Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function

Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis

Chaperoning steroid hormone signaling via reversible acetylation.

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

Molecular determinants of resistance to antiandrogen therapy

Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation

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1963-1972

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scholarly article

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10.1210/ME.2009-0188

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12

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19855091

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2796151

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