Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models
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Chikungunya virus-vector interactionsViral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide DepletionArboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmissionGenetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in MosquitoesSequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in MosquitoesAnalysis of Dengue Virus Genetic Diversity during Human and Mosquito Infection Reveals Genetic ConstraintsGain-of-Function Research and the Relevance to Clinical Practice.Next generation sequencing of DNA-launched Chikungunya vaccine virus.Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness.RNA virus population diversity, an optimum for maximal fitness and virulence.Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.Comparing competitive fitness of West Nile virus strains in avian and mosquito hosts.Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelityLow-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering Particles.Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple MutagensIFN-dependent and -independent reduction in West Nile virus infectivity in human dermal fibroblasts.Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus.Dynamics of West Nile virus evolution in mosquito vectors.Population Diversity and Collective Interactions during Influenza Virus Infection.Purification and Biochemical Characterisation of Rabbit Calicivirus RNA-Dependent RNA Polymerases and Identification of Non-Nucleoside InhibitorsFavipiravir elicits antiviral mutagenesis during virus replication in vivo.Are RNA Viruses Candidate Agents for the Next Global Pandemic? A Review.Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.Fitness peaks of dengue virus populations.Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.Mosquito bottlenecks alter viral mutant swarm in a tissue and time-dependent manner with contraction and expansion of variant positions and diversity.Emergency Services of Viral RNAs: Repair and Remodeling.Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy.Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects.A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus
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Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Alphavirus mutator variants pr ...... in mammalian and insect models
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Alphavirus mutator variants pr ...... n mammalian and insect models.
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type
label
Alphavirus mutator variants pr ...... in mammalian and insect models
@en
Alphavirus mutator variants pr ...... n mammalian and insect models.
@nl
prefLabel
Alphavirus mutator variants pr ...... in mammalian and insect models
@en
Alphavirus mutator variants pr ...... n mammalian and insect models.
@nl
P2093
P2860
P50
P1433
P1476
Alphavirus mutator variants pr ...... in mammalian and insect models
@en
P2093
Hervé Blanc
Kathryn Rozen-Gagnon
Vanesa Mongelli
P2860
P304
P356
10.1371/JOURNAL.PPAT.1003877
P577
2014-01-16T00:00:00Z