Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
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A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human CellsRole for nucleolin/Nsr1 in the cellular localization of topoisomerase I.Role of DNA topoisomerase I in the transcription of supercoiled rRNA geneInvolvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.Processing of topoisomerase I cleavable complexes into DNA damage by transcription.Transcription-dependent degradation of topoisomerase I-DNA covalent complexesCoordinate regulation of the synthesis of eukaryotic ribosomal proteins.A temperature-sensitive mutation affecting 28S ribosomal RNA production in mammalian cells.Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins.Repopulation of postmitotic nucleoli by preformed RNA. II. Ultrastructure.The relationship of ribosomal RNA synthesis to the formation of segregated nucleoli and nucleolus-like bodies.Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium.Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcriptionIncreased transcription and decreased degradation control and recovery of liver ribosomes after a period of protein starvation.Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?
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Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 1971
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
@en
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
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type
label
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
@en
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
@nl
prefLabel
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
@en
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
@nl
P2093
P2860
P356
P1476
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis.
@en
P2093
P2860
P304
P356
10.1073/PNAS.68.12.3009
P407
P577
1971-12-01T00:00:00Z