Physiologically based pharmacokinetic model of lapatinib developed in mice and scaled to humans. - Wikidata - wikimedia - TriplyDB

Physiologically based pharmacokinetic model of lapatinib developed in mice and scaled to humans.

Physiologically based pharmacokinetic model of lapatinib developed in mice and scaled to humans.

http://www.wikidata.org/entity/Q37498669

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New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs A physiologically based pharmacokinetic model of alvespimycin in mice and extrapolation to rats and humans.Incorporation of ABCB1-mediated transport into a physiologically-based pharmacokinetic model of docetaxel in mice.A Whole-Body Physiologically Based Pharmacokinetic Model of Gefitinib in Mice and Scale-Up to Humans Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells.Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies.89Zr-mAb3481 PET for HER3 tumor status assessment during lapatinib treatment.Computational modeling of ERBB2-amplified breast cancer identifies combined ErbB2/3 blockade as superior to the combination of MEK and AKT inhibitors.Challenges Associated with Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making.

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P2860

Physiologically based pharmacokinetic model of lapatinib developed in mice and scaled to humans.

http://www.wikidata.org/entity/Q37498669

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 12 January 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Physiologically based pharmaco ...... in mice and scaled to humans.

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Physiologically based pharmaco ...... in mice and scaled to humans.

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type

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Physiologically based pharmaco ...... in mice and scaled to humans.

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Physiologically based pharmaco ...... in mice and scaled to humans.

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Physiologically based pharmaco ...... in mice and scaled to humans.

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Physiologically based pharmaco ...... in mice and scaled to humans.

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S10928-012-9295-8

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Journal of Pharmacokinetics and Pharmacodynamics

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Physiologically based pharmaco ...... in mice and scaled to humans.

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Daniel L Gustafson

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Susan F Hudachek

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P2860

Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas

Doxorubicin pharmacokinetics: Macromolecule binding, metabolism, and excretion in the context of a physiologic model.

Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data

A phase I and pharmacokinetic study of oral lapatinib administered once or twice daily in patients with solid malignancies.

The influence of age and sex on the clearance of cytochrome P450 3A substrates.

Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.

Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain.

Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects.

CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.

The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.

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s10928-012-9295-8

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157-176

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scholarly article

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10.1007/S10928-012-9295-8

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2

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2013-01-12T00:00:00Z

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3897212

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