Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.
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Emerging mechanisms of molecular pathology in ALSStudies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesisTruncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variantMass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.FTD and ALS--translating mouse studies into clinical trials.Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.Pathomechanisms of TDP-43 in neurodegeneration.Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration
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Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Divergent phenotypes in mutant ...... in TDP-43 transgenic modeling.
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Divergent phenotypes in mutant ...... in TDP-43 transgenic modeling.
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Divergent phenotypes in mutant ...... in TDP-43 transgenic modeling.
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Divergent phenotypes in mutant ...... in TDP-43 transgenic modeling.
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Divergent phenotypes in mutant ...... in TDP-43 transgenic modeling.
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Divergent phenotypes in mutant ...... in TDP-43 transgenic modeling.
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Divergent phenotypes in mutant ...... in TDP-43 transgenic modeling.
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Ashley Cannon
Jada Lewis
Marcelle Altshuler
Simon D'Alton
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10.1371/JOURNAL.PONE.0086513
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2014-01-22T00:00:00Z