Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
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The role of beta-arrestin2 in shaping fMRI BOLD responses to dopaminergic stimulationβ-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds.Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.Hepatic β-arrestin 2 is essential for maintaining euglycemia.D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.GPCR desensitization: Acute and prolonged phases.Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse.G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms.Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia.Dopamine D2 Receptors Modulate Pyramidal Neurons in Mouse Medial Prefrontal Cortex through a Stimulatory G-Protein Pathway.How Ligands Illuminate GPCR Molecular Pharmacology.Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.Biased signalling: from simple switches to allosteric microprocessors.Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression.Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.Deletion of dopamine D2 receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes.
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Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on December 2016
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Distinct cortical and striatal ...... antipsychotic-like properties.
@en
Distinct cortical and striatal ...... antipsychotic-like properties.
@nl
type
label
Distinct cortical and striatal ...... antipsychotic-like properties.
@en
Distinct cortical and striatal ...... antipsychotic-like properties.
@nl
prefLabel
Distinct cortical and striatal ...... antipsychotic-like properties.
@en
Distinct cortical and striatal ...... antipsychotic-like properties.
@nl
P2093
P2860
P921
P356
P1476
Distinct cortical and striatal ...... antipsychotic-like properties
@en
P2093
Bryan L Roth
Emiliana Borrelli
John D McCorvy
Joshua C Snyder
Marc G Caron
Nikhil M Urs
Patricio O'Donnell
Ramona M Rodriguiz
Steven M Gee
P2860
P304
E8178-E8186
P356
10.1073/PNAS.1614347113
P407
P577
2016-12-01T00:00:00Z