Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis.
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Learning from the past for TB drug discovery in the futureEmerging Approaches to Tuberculosis Drug Development: At Home in the Metabolome.Metabolomic strategies for the identification of new enzyme functions and metabolic pathwaysMycobacterium tuberculosis metabolismDisruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in miceIn silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatmentUntargeted Metabolomics To Ascertain Antibiotic Modes of Action.Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.The future for early-stage tuberculosis drug discoveryThe Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan.Neglected diseases prioritized in Brazil under the perspective of metabolomics: A review.Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target.Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis.Identification of novel mutations associated with cycloserine resistance in Mycobacterium tuberculosis.Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance.The role of metabolomics in tuberculosis treatment research.Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.The role of the CroR response regulator in resistance of Enterococcus faecalis to D-cycloserine is defined using an inducible receiver domain.Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability.Application of Proteomic Approaches to Accelerate Drug Development for Psychiatric Disorders.Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine.Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion.Stress-Induced Reorganization of the Mycobacterial Membrane Domain.Application of Multiplex Biomarker Approaches to Accelerate Drug Discovery and Development.Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions.d-Alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans.
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Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Metabolomics Reveal d-Alanine: ...... in Mycobacterium tuberculosis.
@en
Metabolomics Reveal d-Alanine: ...... in Mycobacterium tuberculosis.
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type
label
Metabolomics Reveal d-Alanine: ...... in Mycobacterium tuberculosis.
@en
Metabolomics Reveal d-Alanine: ...... in Mycobacterium tuberculosis.
@nl
prefLabel
Metabolomics Reveal d-Alanine: ...... in Mycobacterium tuberculosis.
@en
Metabolomics Reveal d-Alanine: ...... in Mycobacterium tuberculosis.
@nl
P2860
P356
P1476
Metabolomics Reveal d-Alanine: ...... in Mycobacterium tuberculosis.
@en
P2093
Gareth A Prosser
Luiz P S de Carvalho
P2860
P304
P356
10.1021/ML400349N
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2013-10-05T00:00:00Z