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Identification of novel CK2 inhibitors with a benzofuran scaffold by novel non-radiometric in vitro assays.Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer.Antitumoral activity of allosteric inhibitors of protein kinase CK2.Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cellsCellular regulators of protein kinase CK2.Regulation of taurine transport systems by protein kinase CK2 in mammalian cells.Protein kinase CK2 inhibitors: a patent review.Interactions of natural polyamines with mammalian proteins.Rational Design of Coumarin Derivatives as CK2 Inhibitors by Improving the Interaction with the Hinge Region.Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.Benzimidazole inhibitors of protein kinase CK2 potently inhibit the activity of atypical protein kinase Rio1New insights on thyroid hormone mediated regulation of herpesvirus infections.Exploring the prominent performance of CX-4945 derivatives as protein kinase CK2 inhibitors by a combined computational study.Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors.Exploring the Pivotal Role of the CK2 Hinge Region Sub-Pocket in Binding with Tricyclic Quinolone Analogues by Computational Analysis.Phospholipases and the Network of Auxin Signal Transduction with ABP1 and TIR1 as Two Receptors: A Comprehensive and Provocative Model.Generation and quantitative proteomics analysis of CK2α/α'(-/-) cells.Inhibition of Protein Kinase CK2 Prevents Adipogenic Differentiation of Mesenchymal Stem Cells Like C3H/10T1/2 CellsEffects of CK2 inhibition in cultured fibroblasts from Type 1 Diabetic patients with or without nephropathy.The role of the N-terminal domain in the regulation of the "constitutively active" conformation of protein kinase CK2α: insight from a molecular dynamics investigation.Insights into the Impact of Linker Flexibility and Fragment Ionization on the Design of CK2 Allosteric Inhibitors: Comparative Molecular Dynamics Simulation Studies.A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors.Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2.Underlying mechanisms of cyclic peptide inhibitors interrupting the interaction of CK2α/CK2β: comparative molecular dynamics simulation studies.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
How druggable is protein kinase CK2?
@en
How druggable is protein kinase CK2?
@nl
type
label
How druggable is protein kinase CK2?
@en
How druggable is protein kinase CK2?
@nl
prefLabel
How druggable is protein kinase CK2?
@en
How druggable is protein kinase CK2?
@nl
P356
P1476
How druggable is protein kinase CK2?
@en
P2093
Andrea Bortolato
P304
P356
10.1002/MED.20164
P577
2010-05-01T00:00:00Z