Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.
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Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migrationSuppression of uPAR retards radiation-induced invasion and migration mediated by integrin β1/FAK signaling in medulloblastoma.α3β1 integrin promotes radiation-induced migration of meningioma cellsCharacterization of a murine model of metastatic human non-small cell lung cancer and effect of CXCR4 inhibition on the growth of metastasesA new class of orthosteric uPAR·uPA small-molecule antagonists are allosteric inhibitors of the uPAR·vitronectin interactionPlectin as a prognostic marker in non-metastatic oral squamous cell carcinomaLipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells.Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor.Role of integrins in regulating proteases to mediate extracellular matrix remodelingMMP-9 and uPAR regulated glioma cell migrationRole of urokinase receptor in tumor progression and development.Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2Involvement of urokinase-type plasminogen activator system in cancer: an overview.A novel peptide blocking cancer cell invasion by structure-based drug design.uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis.Invasive potential of melanoma cells correlates with the expression of MT1-MMP and regulated by modulating its association with motility receptors via N-glycosylation on the receptors.Human sprouty1 suppresses urokinase receptor-stimulated cell migration and invasion.Urokinase induces stromal cell-derived factor-1 expression in human hepatocellular carcinoma cells.uPA-derived peptide, Å6 is involved in the suppression of lipopolysaccaride-promoted inflammatory osteoclastogenesis and the resultant bone loss.An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo.Urokinase-type plasminogen activator receptor inhibits apoptosis in triple-negative breast cancer through miR-17/20a suppression of death receptors 4 and 5.uPA-uPAR molecular complex is involved in cell signaling during neuronal migration and neuritogenesis.Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity.
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Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Signaling through urokinase an ...... ractions with beta1 integrins.
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Signaling through urokinase an ...... ractions with beta1 integrins.
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type
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Signaling through urokinase an ...... ractions with beta1 integrins.
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Signaling through urokinase an ...... ractions with beta1 integrins.
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Signaling through urokinase an ...... ractions with beta1 integrins.
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Signaling through urokinase an ...... ractions with beta1 integrins.
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P2093
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Signaling through urokinase an ...... ractions with beta1 integrins.
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Alexis N Brumwell
Chi-Hui Tang
Harold A Chapman
Marla L Hill
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P304
P356
10.1242/JCS.029769
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P577
2008-10-21T00:00:00Z