PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. - Wikidata - wikimedia - TriplyDB

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

http://www.wikidata.org/entity/Q37527357

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The Antibiotic Drug Tigecycline: A Focus on its Promising Anticancer Properties Revisiting the hallmarks of cancer.Tissue-specific tumorigenesis: context matters.Hepatic MiR-291b-3p Mediated Glucose Metabolism by Directly Targeting p65 to Upregulate PTEN Expression.PI3Kδ and primary immunodeficiencies.Targeting B cells in treatment of autoimmunity.The functions of tumor suppressor PTEN in innate and adaptive immunity.mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL.Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.The PI3K Pathway in Human Disease.Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN.Fine tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation.The expression pattern of Bcl11a, Mdm2 and Pten genes in B-cell acute lymphoblastic leukemia.Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse.A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses.A Brake for B Cell Proliferation: Appropriate responses to metabolic stress are crucial to maintain B cell viability and prevent malignant outgrowth.The impact of phosphatases on proliferative and survival signaling in cancer.Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma.Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

http://www.wikidata.org/entity/Q37527357

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 14 March 2016

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

@en

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

@nl

type

label

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

@en

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

@nl

prefLabel

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

@en

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

@nl

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Nature Medicine

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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

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Ari Melnick

http://www.w3.org/2001/XMLSchema#string

Giovanni Cazzaniga

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Hassan Jumaa

http://www.w3.org/2001/XMLSchema#string

Hong Wu

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Huimin Geng

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Kadriye Nehir Cosgun

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Lai N Chan

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Maike Buchner

http://www.w3.org/2001/XMLSchema#string

Marcus Dühren von Minden

http://www.w3.org/2001/XMLSchema#string

Markus Müschen

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P2860

A census of human cancer genes

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Comparative isoschizomer profiling of cytosine methylation: the HELP assay

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex

BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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379-387

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scholarly article

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10.1038/NM.4062

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4

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22

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Andreas Hochhaus

Markus Müschen

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2016-03-14T00:00:00Z

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298332501

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26974310

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