Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.
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N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidasesLysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes.Pharmacological Chaperone Therapy: Preclinical Development, Clinical Translation, and Prospects for the Treatment of Lysosomal Storage Disorders.Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component.Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.
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Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 October 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Evidence that small molecule e ...... avioral phenotype in Dutch APP
@nl
Evidence that small molecule e ...... ction of ganglioside-bound Aβ.
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type
label
Evidence that small molecule e ...... avioral phenotype in Dutch APP
@nl
Evidence that small molecule e ...... ction of ganglioside-bound Aβ.
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prefLabel
Evidence that small molecule e ...... avioral phenotype in Dutch APP
@nl
Evidence that small molecule e ...... ction of ganglioside-bound Aβ.
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Evidence that small molecule e ...... ction of ganglioside-bound Aβ.
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A C Stevens
A D Morant
B A Wustman
D J Lockhart
E M Knight
E R Sjoberg
H N Williams
J C Kottwitz
J W Steele
K Yanagisawa
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P2888
P304
P356
10.1038/MP.2014.135
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P577
2014-10-28T00:00:00Z