Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
about
CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffoldsRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisIdentification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model systemNaphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanismSterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasisExamination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.TbUNC119 and its binding protein complex are essential for propagation, motility, and morphogenesis of Trypanosoma brucei procyclic form cells.Huprines as a new family of dual acting trypanocidal-antiplasmodial agentsRisedronate metal complexes potentially active against Chagas disease.Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatidsThe concept of privileged structures in rational drug design: focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases.Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin.Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations.Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases.Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds.New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.Synthesis, SAR and biological studies of sugar amino acid-based almiramide analogues: N-methylation leads the way.Chemistry and biology of multicomponent reactions.Aspartic peptidases of human pathogenic trypanosomatids: perspectives and trends for chemotherapy.Microtubules as antifungal and antiparasitic drug targets.Phosphagen kinases of parasites: unexplored chemotherapeutic targets.Mitochondria and trypanosomatids: targets and drugs.Molecular recognition in chemical and biological systems.Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis.Identification in silico and in vitro of novel trypanosomicidal drug-like compounds.Hybrid lipoic acid derivatives to attack prion disease on multiple fronts.Multi-Anti-Parasitic Activity of Arylidene Ketones and Thiazolidene Hydrazines against Trypanosoma cruzi and Leishmania spp.Simple dialkyl pyrazole-3,5-dicarboxylates show in vitro and in vivo activity against disease-causing trypanosomatids.Cyanobacteria, Lyngbya aestuarii and Aphanothece bullosa as antifungal and antileishmanial drug resources.Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana.A new series of heteroleptic oxidovanadium(IV) compounds with phenanthroline-derived co-ligands: selective Trypanosoma cruzi growth inhibitors.Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments.Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones.Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.Multiple target-based pharmacophore design from active site structures.Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase.Glycosylated metal chelators as anti-parasitic agents with tunable selectivity.Multitarget Drug Discovery and Polypharmacology.
P2860
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P2860
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Neglected tropical diseases: m ...... st Trypanosoma and Leishmania.
@en
Neglected tropical diseases: m ...... st Trypanosoma and Leishmania.
@nl
type
label
Neglected tropical diseases: m ...... st Trypanosoma and Leishmania.
@en
Neglected tropical diseases: m ...... st Trypanosoma and Leishmania.
@nl
prefLabel
Neglected tropical diseases: m ...... st Trypanosoma and Leishmania.
@en
Neglected tropical diseases: m ...... st Trypanosoma and Leishmania.
@nl
P356
P1476
Neglected tropical diseases: m ...... st Trypanosoma and Leishmania.
@en
P2093
Andrea Cavalli
Maria Laura Bolognesi
P304
P356
10.1021/JM9004835
P407
P577
2009-12-01T00:00:00Z