Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
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Targeting the androgen receptor in prostate and breast cancer: several new agents in developmentTargeting highly expressed extracellular HSP90 in breast cancer stem cells inhibits tumor growth in vitro and in vivo.The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.A high-throughput assay for small molecule destabilizers of the KRAS oncoproteinHSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy.HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells.Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast CancerHsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.Ganetespib, an HSP90 inhibitor, kills Epstein-Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.Human Epidermal Growth Factor Receptor 2-Targeted PET/Single- Photon Emission Computed Tomography Imaging of Breast Cancer: Noninvasive Measurement of a Biomarker Integral to Tumor Treatment and Prognosis.In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell LinesHeat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus.Targeting protein quality control pathways in breast cancer.Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens.Current Therapies for Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients.Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells.Heat shock factor 1 confers resistance to lapatinib in ERBB2-positive breast cancer cells.
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Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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name
Targeted inhibition of Hsp90 b ...... rum of breast cancer subtypes.
@en
Targeted inhibition of Hsp90 b ...... rum of breast cancer subtypes.
@nl
type
label
Targeted inhibition of Hsp90 b ...... rum of breast cancer subtypes.
@en
Targeted inhibition of Hsp90 b ...... rum of breast cancer subtypes.
@nl
prefLabel
Targeted inhibition of Hsp90 b ...... rum of breast cancer subtypes.
@en
Targeted inhibition of Hsp90 b ...... rum of breast cancer subtypes.
@nl
P2093
P2860
P1476
Targeted inhibition of Hsp90 b ...... rum of breast cancer subtypes.
@en
P2093
Chaohua Zhang
David A Proia
Donald L Smith
Jaime Acquaviva
Julie C Friedland
P2860
P2888
P356
10.1007/S10637-013-9971-6
P577
2013-05-18T00:00:00Z