Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.
about
A novel mouse model of a patient mucolipidosis II mutation recapitulates disease pathologyMannose 6 phosphorylation of lysosomal enzymes controls B cell functions.Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription controlCathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting.New targets for old diseases: lessons from mucolipidosis type II.TGN exit of the cation-independent mannose 6-phosphate receptor does not require acid hydrolase binding.Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II.Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View.Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting.Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I.Early characteristic radiographic changes in mucolipidosis II.N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification.Lysosomal Ca2+ Signaling is Essential for Osteoclastogenesis and Bone Remodeling.Mucolipidosis type III, a series of adult patients
P2860
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P2860
Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 15 October 2013
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Decreased bone formation and i ...... bone loss in mucolipidosis II.
@en
Decreased bone formation and i ...... bone loss in mucolipidosis II.
@nl
type
label
Decreased bone formation and i ...... bone loss in mucolipidosis II.
@en
Decreased bone formation and i ...... bone loss in mucolipidosis II.
@nl
prefLabel
Decreased bone formation and i ...... bone loss in mucolipidosis II.
@en
Decreased bone formation and i ...... bone loss in mucolipidosis II.
@nl
P2093
P2860
P356
P1476
Decreased bone formation and i ...... bone loss in mucolipidosis II
@en
P2093
Antonio Virgilio Failla
Elisabeth Schöne
Jan Malte Pestka
Kathrin Karkmann
Katrin Kollmann
Michael Amling
Michaela Schweizer
Philip Catala-Lehnen
Rene Santer
Robert Percy Marshall
P2860
P304
P356
10.1002/EMMM.201302979
P50
P577
2013-10-15T00:00:00Z