The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
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Epithelial cell polarity determinant CRB3 in cancer developmentTargeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosisThe Family of Crumbs Genes and Human DiseaseModularity in protein complex and drug interactions reveals new polypharmacological propertiesDomain-specific functions of Stardust in Drosophila embryonic developmentCrumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein ExpandedStructure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complexMolecular Pathways: Hippo Signaling, a Critical Tumor Suppressor.Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesinAtypical protein kinase C controls sea urchin ciliogenesis.Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity.chaoptin, prominin, eyes shut and crumbs form a genetic network controlling the apical compartment of Drosophila photoreceptor cellsThe severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.A local autocrine axis in the testes that regulates spermatogenesis.Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriersFormation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epitheliaThe Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarizationLoss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.Evolution of microRNAs and the diversification of species.Anisotropy of Crumbs and aPKC drives myosin cable assembly during tube formation.Crumbs affects protein dynamics in anterior regions of the developing Drosophila embryoNovel neuroprotective function of apical-basal polarity gene crumbs in amyloid beta 42 (aβ42) mediated neurodegenerationApical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of DrosophilaApical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardustThe C. elegans Crumbs family contains a CRB3 homolog and is not essential for viability.Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease.Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse modelGeneration of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafishThe transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC.Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V.A genome-wide resource for the analysis of protein localisation in Drosophila.Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.An evolutionary shift in the regulation of the Hippo pathway between mice and fliesCrumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell deathThe Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity.Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant.Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila.LIN7A is a major determinant of cell-polarity defects in breast carcinomas
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P2860
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
@en
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
@nl
type
label
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
@en
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
@nl
prefLabel
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
@en
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
@nl
P356
P1476
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
@en
P2093
Elisabeth Knust
Natalia A Bulgakova
P304
P356
10.1242/JCS.023648
P407
P577
2009-08-01T00:00:00Z