Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells.
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Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine ProteaseBotulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassayMulti-wavelength Spatial LED illumination based detector for in vitro detection of Botulinum Neurotoxin A Activity.Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis.Llama single domain antibodies specific for the 7 botulinum neurotoxin serotypes as heptaplex immunoreagents.A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity.Lensless CCD-based fluorometer using a micromachined optical Söller collimator.Improved detection of botulinum neurotoxin serotype A by Endopep-MS through peptide substrate modification.Botulinum toxin: bioweapon & magic drugHypersensitive detection and quantitation of BoNT/A by IgY antibody against substrate linear-peptideEmbryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discoveryA high content imaging assay for identification of Botulinum neurotoxin inhibitorsSensing the deadliest toxin: technologies for botulinum neurotoxin detection.In vitro detection and quantification of botulinum neurotoxin type e activity in avian bloodRecent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discoveryNovel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detectionNewly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.Progress in cell based assays for botulinum neurotoxin detectionBotulism diagnostics: from clinical symptoms to in vitro assays.Characterization of botulinum neurotoxin A subtypes 1 through 5 by investigation of activities in mice, in neuronal cell cultures, and in vitro.Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodiesA neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies.Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins.Botulinum neurotoxin: where are we with detection technologies?Alpha-latrotoxin rescues SNAP-25 from BoNT/A-mediated proteolysis in embryonic stem cell-derived neurons.Targeting-triggered porphysome nanostructure disruption for activatable photodynamic therapy.Development of a Cell-Based Functional Assay for the Detection of Clostridium botulinum Neurotoxin Types A and E.Synaptic vesicle chips to assay botulinum neurotoxins.Attomolar detection of botulinum toxin type A in complex biological matrices.A Novel Surface Plasmon Resonance Biosensor for the Rapid Detection of Botulinum Neurotoxins.Further optimization of peptide substrate enhanced assay performance for BoNT/A detection by MALDI-TOF mass spectrometry.Development of an in vitro activity assay as an alternative to the mouse bioassay for Clostridium botulinum neurotoxin type A.Nanopore sensing of botulinum toxin type B by discriminating an enzymatically cleaved Peptide from a synaptic protein synaptobrevin 2 derivative.Botulinum toxin suppression of CNS network activity in vitro.Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity.The osmolyte trimethylamine N-oxide (TMAO) increases the proteolytic activity of botulinum neurotoxin light chains A, B, and E: implications for enhancing analytical assay sensitivity.Analysis of secreted protein profile and enzymatic activities from Corynebacterium diphtheriae and Bordetella pertussis on production batch media using peptide quenched fluorescent substrates.Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity.Mechanism of substrate recognition by botulinum neurotoxin serotype A.
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P2860
Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2004
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Using fluorescent sensors to d ...... in vitro and in living cells.
@en
Using fluorescent sensors to d ...... in vitro and in living cells.
@nl
type
label
Using fluorescent sensors to d ...... in vitro and in living cells.
@en
Using fluorescent sensors to d ...... in vitro and in living cells.
@nl
prefLabel
Using fluorescent sensors to d ...... in vitro and in living cells.
@en
Using fluorescent sensors to d ...... in vitro and in living cells.
@nl
P2093
P2860
P356
P1476
Using fluorescent sensors to d ...... in vitro and in living cells.
@en
P2093
Edwin R Chapman
Eric A Johnson
William H Tepp
P2860
P304
14701-14706
P356
10.1073/PNAS.0404107101
P407
P577
2004-10-01T00:00:00Z