The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.
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Targeting the Eph System with Peptides and Peptide ConjugatesEph receptors as therapeutic targets in glioblastomaThe homeobox only protein homeobox (HOPX) and colorectal cancerEphs and Ephrins in malignant gliomasCD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cellsCrucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylationAnalysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells.Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells.The evolving landscape of glioblastoma stem cells.Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy.Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system.EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy.Identification of molecular pathways facilitating glioma cell invasion in situ.Eph receptor tyrosine kinases in cancer stem cellsUniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations.A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.New agents for targeting of IL-13RA2 expressed in primary human and canine brain tumors.Adenoviruses using the cancer marker EphA2 as a receptor in vitro and in vivo by genetic ligand insertion into different capsid scaffolds.Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype.EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or LeukemiaCancer stem cells in glioblastomaCDC20 maintains tumor initiating cells.EphA2 Receptor Unliganded Dimers Suppress EphA2 Pro-tumorigenic Signaling.EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal CancerInhibition of BRAF and BRAF+MEK drives a metastatic switch in melanoma.Glioma surgical aspirate: a viable source of tumor tissue for experimental research.Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes.Aptamer identification of brain tumor-initiating cells.Simultaneous targeting of Eph receptors in glioblastomaAntiangiogenic therapy for high-grade gliomas: current concepts and limitations.Therapeutic targeting of EPH receptors and their ligands.Glioma stem cells: turpis omen in nomen? (The evil in the name?).Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics.Cancer stem cells: perspectives for therapeutic targeting.Eph receptors and ephrins: therapeutic opportunities.EphA3 biology and cancer.Eph family co-expression patterns define unique clusters predictive of cancer phenotype.Inhibiting Eph kinase activity may not be "Eph"ective for cancer treatment.
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P2860
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The EphA2 receptor drives self ...... ells from human glioblastomas.
@en
The EphA2 receptor drives self ...... ells from human glioblastomas.
@nl
type
label
The EphA2 receptor drives self ...... ells from human glioblastomas.
@en
The EphA2 receptor drives self ...... ells from human glioblastomas.
@nl
prefLabel
The EphA2 receptor drives self ...... ells from human glioblastomas.
@en
The EphA2 receptor drives self ...... ells from human glioblastomas.
@nl
P2093
P2860
P50
P1433
P1476
The EphA2 receptor drives self ...... cells from human glioblastomas
@en
P2093
Alberto Visioli
Annunziato Mangiola
Brent A Reynolds
Carmelo Anile
Elena B Pasquale
Giulio Maira
Jason T Huse
Laura Cajola
Nadia Zanetti
P2860
P304
P356
10.1016/J.CCR.2012.11.005
P50
P577
2012-12-01T00:00:00Z