Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. - Wikidata - wikimedia - TriplyDB

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

http://www.wikidata.org/entity/Q37579675

about

The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi Binding Modes of Zaragozic Acid A to Human Squalene Synthase and Staphylococcal Dehydrosqualene Synthase CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase Sterol biosynthesis is required for heat resistance but not extracellular survival in leishmania Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis A Computational Methodology to Overcome the Challenges Associated With the Search for Specific Enzyme Targets to Develop Drugs Against Leishmania major.In vitro additive interaction between ketoconazole and antimony against intramacrophage Leishmania (Leishmania) amazonensis amastigotes Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions.Drug strategies targeting CYP51 in neglected tropical diseases In vitro activity of the antifungal azoles itraconazole and posaconazole against Leishmania amazonensis.Identification of pathogenicity-related genes in the vascular wilt fungus Verticillium dahliae by Agrobacterium tumefaciens-mediated T-DNA insertional mutagenesis Potent In Vitro Antiproliferative Synergism of Combinations of Ergosterol Biosynthesis Inhibitors against Leishmania amazonensis.Dynamics of sterol synthesis during development of Leishmania spp. parasites to their virulent form.Metal-drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells The subcellular distribution of small molecules: from pharmacokinetics to synthetic biology Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease.Identification of Novel Raft Marker Protein, FlotP in Bacillus anthracis.Antiproliferative, Ultrastructural, and Physiological Effects of Amiodarone on Promastigote and Amastigote Forms of Leishmania amazonensis.Antileishmanial effect of mevastatin is due to interference with sterol metabolism.Δ(24)-Sterol Methyltransferase Plays an Important Role in the Growth and Development of Sporothrix schenckii and Sporothrix brasiliensis.Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art.New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi Recent developments in trans-sialidase inhibitors of Trypanosoma cruzi.Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii.Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii.In vivo anti-Trypanosoma cruzi activity of hydro-ethanolic extract and isolated active principles from Aristeguietia glutinosa and mechanism of action studies.FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine.Toxicity and Loss of Mitochondrial Membrane Potential Induced by Alkyl Gallates in Trypanosoma cruzi.Liposomal formulation of turmerone-rich hexane fractions from Curcuma longa enhances their antileishmanial activity.Induction of mitochondrial dysfunction and oxidative stress in Leishmania donovani by orally active clerodane diterpene Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis.

P2860

Q26829884-FA9D3210-9879-4538-B234-34D067FD31E3 Q27660510-09C241C8-8DF9-470C-8211-9CACC6831CF8 Q27662136-EDF988EC-B4CF-4EE2-82FB-EFF9B7C3164E Q27678314-6DAAFE2F-EF76-4E81-9947-15304D6C2FA4 Q28477209-2BFD2820-DAFC-4F19-A95D-F1F18645E76D Q28481694-5DCE0B0F-C9F7-4015-88E5-8CAC2ED3BE0B Q28485411-B8E5AC23-1957-4BFC-8A60-0B579F1507D1 Q28544037-CE39EA16-BB17-468D-97F0-3E9C83781131 Q28544093-7CBE5A86-0A98-4509-9BA3-E90960A4A1C0 Q28553573-21F95AD4-6106-4D3B-9339-B6A78BE5F3B3 Q28714212-BAF44AE7-08ED-402C-8AF4-F60CD240EB13 Q28727454-F3E52377-AF6B-4A1C-8115-BE092DABE7A0 Q33797941-945CD39A-8E0D-4E3C-892F-A35A2A4CFAF4 Q33853773-66AAE079-56EF-4203-AFCF-8EA5711475B3 Q33898663-828B6826-3910-4AB1-87A8-5A18537C8F8C Q33983190-DCD70E98-33FD-4FEB-877D-311E7AB96EF2 Q34622554-F791B156-363C-470C-9025-4D1ECB891476 Q35077994-2B13B03C-73EB-4840-B507-89409C5913C7 Q35243128-5C4D187A-9708-4D22-8E8B-F0F09951D310 Q36075944-71EEDE94-BE05-4131-98D9-9038FF144B34 Q36793673-D07279E3-34D3-4866-8852-AED636B988DF Q37198743-597A40BF-FDCC-45E3-9B76-0290EAED5B86 Q37909301-1A7B7DBF-19DD-419A-9FBA-2B59EEA7826B Q38286350-8109B178-6E5C-422F-A2F6-8A3C1BC2E5AB Q38518717-1E2A9CFC-2B20-433E-9112-F155F08E72D7 Q38805947-A79897FF-D2CB-41E6-B1F5-C76530C40E59 Q38852074-8D8B7877-F3F5-44A0-9838-C5B9614DE707 Q38913538-3CA3E92C-A3AB-4635-9DB2-D5A2D7A93A74 Q38939544-9EED4E2F-8E2F-4384-AA3A-62D5AE7E33F3 Q39012627-66D90F5E-38BF-4BA5-9637-31EE2CD0CC31 Q39111617-B0D0A0A1-7F79-4FC1-ABEC-6809402B35F3 Q39220490-A1FED446-4A48-453B-9239-37752B16B357 Q39307254-F6FBB95C-AFD3-4496-A16C-085AA2DAD064 Q39554107-9C37BF33-3652-40D5-A33F-D4ED704A1678 Q41234890-D91AC566-0D12-4D95-9B3D-0FC0486A00B5 Q41836534-BE677800-2C94-4484-AD28-771CCA1E91C7 Q41983753-827EC781-68F4-499D-BC14-5A5B9E24C816 Q42017568-ECA43C40-5735-45C2-9F11-6C19D18FC59A Q42109679-78185BCC-F747-4402-AC90-1789AC36C18D Q42255891-07D8E0DB-74CD-4905-A02A-03C5FC7C8904

P2860

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

http://www.wikidata.org/entity/Q37579675

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 05 August 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

@en

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

@nl

type

label

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

@en

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

@nl

prefLabel

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

@en

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

@nl

P1433

Q37579675-8674087C-5A0F-4926-A962-A6A79B83EDAF

P1476

Q37579675-82BCB5DE-17F0-4BFA-8202-F3B26F840A65

P2093

Q37579675-A09070E6-5F87-4BD4-BF04-08DA92C0E3F8

Q37579675-D709E75E-3E44-4796-AB3E-666C7D45D9EB

P2860

Q37579675-02564DC1-4F84-4906-B1B9-A2A2348C7183

Q37579675-0433C9DC-75CC-4D99-88E6-792C1E776897

Q37579675-04AA05C0-9DB5-4A80-915B-C873DB4136FB

Q37579675-04FC9EB9-53F9-4F9B-BD47-CAB2057AD1A2

Q37579675-09AECF56-DB38-4C2B-BC2F-D37F2B100C7E

Q37579675-0AE2B9C6-D906-4BCA-8E13-843B22D1C510

Q37579675-13A77A6D-ED2B-4431-A4FD-3064D302BA68

Q37579675-15F85434-627C-4618-B7FA-A10CAEA93881

Q37579675-16E24E93-4984-4A02-B7A3-EB6F93F3E236

Q37579675-19F444DF-8CF4-4995-96AC-07A5D08C03F4

P304

Q37579675-4549A51D-016F-489F-BE6B-15C891A8FA0C

P31

Q37579675-2EB78A1E-02C4-40EB-BBD7-9D22401ED172

P356

Q37579675-85A94E4E-9FD5-4CD4-AB11-49271D3C1D21

P478

Q37579675-751F477C-3D70-4F74-8948-1D4DBB40B3E1

P577

Q37579675-71314650-72A9-4243-9DA1-71C9971F664E

P5875

Q37579675-2A57CFD6-0166-45F1-9995-341190D78486

P698

Q37579675-DF490263-A7C6-4319-913F-121D3EAC7E50

P932

Q37579675-46F1ECE4-1C5C-4C79-B212-76582E0B0C5E

P356

P1433

Interdisciplinary Perspectives on Infectious Diseases

P1476

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

@en

P2093

Juliany Cola Fernandes Rodrigues

http://www.w3.org/2001/XMLSchema#string

Wanderley de Souza

http://www.w3.org/2001/XMLSchema#string

P2860

Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.

The developmental cell biology of Trypanosoma brucei

The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol

Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase

Squalene synthase inhibitors : clinical pharmacology and cholesterol-lowering potential

The activity of ketoconazole and other azoles against Trypanosoma cruzi: biochemistry and chemotherapeutic action in vitro

Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans

History of the events leading to the formulation of the apoptosis concept

Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms

Receptors for the host low density lipoproteins on the hemoflagellate Trypanosoma brucei: purification and involvement in the growth of the parasite

P304

642502

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1155/2009/642502

http://www.w3.org/2001/XMLSchema#string

P478

2009

http://www.w3.org/2001/XMLSchema#string

P577

2009-08-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26741834

http://www.w3.org/2001/XMLSchema#string

P698

19680554

http://www.w3.org/2001/XMLSchema#string

P932

2721973

http://www.w3.org/2001/XMLSchema#string