A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer
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Prep1, a novel functional partner of Pbx proteins.The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativityPBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteinsStructure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complexLock and key binding of the HOX YPWM peptide to the PBX homeodomainA conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5cRole of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complexGenome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in DrosophilaChick Lrrn2, a novel downstream effector of Hoxb1 and Shh, functions in the selective targeting of rhombomere 4 motor neuronsThe C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm.Hox specificity unique roles for cofactors and collaborators.Autoinhibition as a transcriptional regulatory mechanism.EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling.Temperature-sensitive protein-DNA dimerizers.Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.Point mutations within and outside the homeodomain identify sequences required for proboscipedia homeotic function in Drosophila.Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers.Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes).Regulation by homeoproteins: a comparison of deformed-responsive elements.The Drosophila genes disconnected and disco-related are redundant with respect to larval head development and accumulation of mRNAs from deformed target genesA green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryoFunctional and regulatory interactions between Hox and extradenticle genes.The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila.The control of trunk Hox specificity and activity by ExtradenticleChIP-Seq and RNA-Seq analyses identify components of the Wnt and Fgf signaling pathways as Prep1 target genes in mouse embryonic stem cells.Homeotic functions of the Teashirt transcription factor during adult Drosophila development.Prospero is a panneural transcription factor that modulates homeodomain protein activity.Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20Hox genes, evo-devo, and the case of the ftz geneDetermination of floral organ identity by Arabidopsis MADS domain homeotic proteins AP1, AP3, PI, and AG is independent of their DNA-binding specificity.Redox signaling in cardiac renewal.Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites.Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7.E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblastsTargeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly.Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex.Dissecting the functional specificities of two Hox proteins.
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P2860
A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A structural model for a homeo ...... HOX protein in the heterodimer
@en
A structural model for a homeo ...... OX protein in the heterodimer.
@nl
type
label
A structural model for a homeo ...... HOX protein in the heterodimer
@en
A structural model for a homeo ...... OX protein in the heterodimer.
@nl
prefLabel
A structural model for a homeo ...... HOX protein in the heterodimer
@en
A structural model for a homeo ...... OX protein in the heterodimer.
@nl
P2860
P356
P1476
A structural model for a homeo ...... HOX protein in the heterodimer
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.11.5223
P407
P577
1996-05-01T00:00:00Z