Variable region genes for the immunoglobulin framework are assembled from small segments of DNA--a hypothesis.
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Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining regionAmino acid sequence of the variable region of a human mu chain: location of a possible JH segmentAmino acid sequence of the Fv region of a human monoclonal IgM (protein WEA) with antibody activity against 3,4-pyruvylated galactose in Klebsiella polysaccharides K30 and K33Evidence supporting somatic assembly of the DNA segments (minigenes), coding for the framework, and complementarity-determining segments of immunoglobulin variable regions.Immunoglobulin differentiation is dictated by repeated recombination sequences within the V region prototype gene: a hypothesisSome sequence similarities among cloned mouse DNA segments that code for lambda and kappa light chains of immunoglobulins.Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c miceEpstein-Barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology.IgG subclasses and allotypes: from structure to effector functions.Single-domain antibodies and their utility.Chicken immunoglobulin gamma-heavy chains: limited VH gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus.Polymorphism in immunoglobulin heavy chains suggesting gene conversion.Overlapping evolutionary affinities revealed by comparison of amino acid compositions.Fourteen nucleotides in the second complementarity-determining region of a human heavy-chain variable region gene are identical with a sequence in a human D minigene.Evidence indicating independent assortment of framework and complementarity-determining segments of the variable regions of rabbit light chains. Delineation of a possible J minigeneGenetic control of a shared idiotype among antibodies directed to distinct specificities.Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.Organization of kappa light chain genes in germ-line and somatic tissueRestricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies.Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins.Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.Composite human VK genes and a model of their evolution.The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content.Immunoglobulin Tau Heavy Chain (IgT) in Flounder, Paralichthys olivaceus: Molecular Cloning, Characterization, and Expression AnalysesStructural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions.Origins of metabolic diversity: evolutionary divergence by sequence repetition.Recombination between antibody heavy chain variable-region genes: evidence for gene conversionMechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions.Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains.Anti-DNA antibodies, autoimmunity and the immunoglobulin repertoire.From clonal selection to immune networks: induction of silent idiotypes.Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.From the structure of antibodies to the diversification of the immune response.Structural repertoire of immunoglobulin λ light chains.
P2860
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P2860
Variable region genes for the immunoglobulin framework are assembled from small segments of DNA--a hypothesis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1978
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Variable region genes for the ...... segments of DNA--a hypothesis.
@en
Variable region genes for the ...... segments of DNA--a hypothesis.
@nl
type
label
Variable region genes for the ...... segments of DNA--a hypothesis.
@en
Variable region genes for the ...... segments of DNA--a hypothesis.
@nl
prefLabel
Variable region genes for the ...... segments of DNA--a hypothesis.
@en
Variable region genes for the ...... segments of DNA--a hypothesis.
@nl
P2093
P2860
P356
P1476
Variable region genes for the ...... segments of DNA--a hypothesis.
@en
P2093
P2860
P304
P356
10.1073/PNAS.75.5.2429
P407
P577
1978-05-01T00:00:00Z